Synergistic approach of structure-based and ligand-based drug design for the development of selective cannabinod receptor ligands

Por Günther, Robert, Brust, Peter
Publicado em 2012

A 3D-QSAR model for cannabinoid receptor (CB2) ligands derived from aligned pharmacophors

Por Günther, Robert, Deuther-Conrad, Winnie, Moldovan, Rareś, Fischer, Steffen, Brust, Peter
Publicado em 2013

Development of cannabinoid receptor (CB 2 R) ligands for application in PET studies - where to attach the radiolabel?

Por Günther, Robert, Moldovan, Rareş, Lueg, Corinna, Deuther-Conrad, Winnie, Wünsch, Bernhard, Brust, Peter
Publicado em 2014

Cannabinoid receptor type 2 (CB2)-selective N-aryl-oxadiazolyl-propionamides: synthesis, radiolabelling, molecular modelling and biological evaluation

Por Rühl, Thomas, Deuther-Conrad, Winnie, Fischer, Steffen, Günther, Robert, Hennig, Lothar, Krautscheid, Harald, Brust, Peter
Publicado em 2012

Use of 3-[(18)F]fluoropropanesulfonyl chloride as a prosthetic agent for the radiolabelling of amines: Investigation of precursor molecules, labelling conditions and enzymatic stab...

Por Löser, Reik, Fischer, Steffen, Hiller, Achim, Köckerling, Martin, Funke, Uta, Maisonial, Aurélie, Brust, Peter, Steinbach, Jörg
Publicado em 2013

Radiosynthesis and Radiotracer Properties of a 7-(2-[(18)F]Fluoroethoxy)-6-methoxypyrrolidinylquinazoline for Imaging of Phosphodiesterase 10A with PET

Por Funke, Uta, Deuther-Conrad, Winnie, Schwan, Gregor, Maisonial, Aurélie, Scheunemann, Matthias, Fischer, Steffen, Hiller, Achim, Briel, Detlef, Brust, Peter
Publicado em 2012

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ(1) Receptors in the Brain

Por Holl, Katharina, Schepmann, Dirk, Fischer, Steffen, Ludwig, Friedrich-Alexander, Hiller, Achim, Donat, Cornelius K., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard
Publicado em 2014

Radiofluorination and biological evaluation of N-aryl-oxadiazolyl-propionamides as potential radioligands for PET imaging of cannabinoid CB(2) receptors

Por Teodoro, Rodrigo, Moldovan, Rareş-Petru, Lueg, Corinna, Günther, Robert, Donat, Cornelius K, Ludwig, Friedrich-Alexander, Fischer, Steffen, Deuther-Conrad, Winnie, Wünsch, Bernhard, Brust, Peter
Publicado em 2013

Varying Chirality Across Nicotinic Acetylcholine Receptor Subtypes: Selective Binding of Quinuclidine Triazole Compounds

Por Sarasamkan, Jiradanai, Scheunemann, Matthias, Apaijai, Nattayaporn, Palee, Siripong, Parichatikanond, Warisara, Arunrungvichian, Kuntarat, Fischer, Steffen, Chattipakorn, Siriporn, Deuther-Conrad, Winnie, Schüürmann, Gerrit, Brust, Peter, Vajragupta, Opa
Publicado no ACS Med Chem Lett (2016)

Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [(18)F]NS14490

Por Rötering, Sven, Deuther-Conrad, Winnie, Cumming, Paul, Donat, Cornelius K, Scheunemann, Matthias, Fischer, Steffen, Xiong, Guoming, Steinbach, Jörg, Peters, Dan, Sabri, Osama, Bucerius, Jan, Brust, Peter
Publicado em 2014

Development of a New Radiofluorinated Quinoline Analog for PET Imaging of Phosphodiesterase 5 (PDE5) in Brain

Por Liu, Jianrong, Wenzel, Barbara, Dukic-Stefanovic, Sladjana, Teodoro, Rodrigo, Ludwig, Friedrich-Alexander, Deuther-Conrad, Winnie, Schröder, Susann, Chezal, Jean-Michel, Moreau, Emmanuel, Brust, Peter, Maisonial-Besset, Aurélie
Publicado no Pharmaceuticals (Basel) (2016)

PET Imaging Evaluation of [(18)F]DBT-10, a Novel Radioligand Specific to α(7) Nicotinic Acetylcholine Receptors, in Nonhuman Primates

Por Hillmer, Ansel T., Zheng, Ming-Qiang, Li, Songye, Scheunemann, Matthias, Lin, Shu-fei, Holden, Daniel, Labaree, David, Ropchan, Jim, Teodoro, Rodrigo, Deuther-Conrad, Winnie, Carson, Richard E., Brust, Peter, Huang, Yiyun
Publicado no Eur J Nucl Med Mol Imaging (2015)

Radiation dosimetry of the α(4)β(2) nicotinic receptor ligand (+)-[(18)F]flubatine, comparing preclinical PET/MRI and PET/CT to first-in-human PET/CT results

Por Kranz, Mathias, Sattler, Bernhard, Tiepolt, Solveig, Wilke, Stephan, Deuther-Conrad, Winnie, Donat, Cornelius K., Fischer, Steffen, Patt, Marianne, Schildan, Andreas, Patt, Jörg, Smits, René, Hoepping, Alexander, Steinbach, Jörg, Sabri, Osama, Brust, Peter
Publicado no EJNMMI Phys (2016)

Suppressed Fat Appetite after Roux-en-Y Gastric Bypass Surgery Associates with Reduced Brain μ-opioid Receptor Availability in Diet-Induced Obese Male Rats

Por Hankir, Mohammed K., Patt, Marianne, Patt, Jörg T. W., Becker, Georg A., Rullmann, Michael, Kranz, Mathias, Deuther-Conrad, Winnie, Schischke, Kristin, Seyfried, Florian, Brust, Peter, Hesse, Swen, Sabri, Osama, Krügel, Ute, Fenske, Wiebke K.
Publicado no Front Neurosci (2017)

PET Imaging of α(7) Nicotinic Acetylcholine Receptors: A comparative study of [(18)F]ASEM and [(18)F]DBT-10 in non-human primates, and further evaluation of [(18)F]ASEM in humans

Por Hillmer, Ansel T., Li, Songye, Zheng, Ming-Qiang, Scheunemann, Matthias, Lin, Shu-fei, Nabulsi, Nabeel, Holden, Daniel, Pracitto, Richard, Labaree, David, Ropchan, Jim, Teodoro, Rodrigo, Deuther-Conrad, Winnie, Esterlis, Irina, Cosgrove, Kelly P., Brust, Peter, Carson, Richard E., Huang, Yiyun
Publicado no Eur J Nucl Med Mol Imaging (2017)

A novel thermoregulatory role for PDE10A in mouse and human adipocytes

Por Hankir, Mohammed K, Kranz, Mathias, Gnad, Thorsten, Weiner, Juliane, Wagner, Sally, Deuther‐Conrad, Winnie, Bronisch, Felix, Steinhoff, Karen, Luthardt, Julia, Klöting, Nora, Hesse, Swen, Seibyl, John P, Sabri, Osama, Heiker, John T, Blüher, Matthias, Pfeifer, Alexander, Brust, Peter, Fenske, Wiebke K
Publicado no EMBO Mol Med (2016)

Thyroid hormone status defines brown adipose tissue activity and browning of white adipose tissues in mice

Por Weiner, Juliane, Kranz, Mathias, Klöting, Nora, Kunath, Anne, Steinhoff, Karen, Rijntjes, Eddy, Köhrle, Josef, Zeisig, Vilia, Hankir, Mohammed, Gebhardt, Claudia, Deuther-Conrad, Winnie, Heiker, John T., Kralisch, Susan, Stumvoll, Michael, Blüher, Matthias, Sabri, Osama, Hesse, Swen, Brust, Peter, Tönjes, Anke, Krause, Kerstin
Publicado no Sci Rep (2016)

Radiolabelled Molecules for Brain Imaging with PET and SPECT

Publicado em 2020