PET Imaging of α(7) Nicotinic Acetylcholine Receptors: A comparative study of [(18)F]ASEM and [(18)F]DBT-10 in non-human primates, and further evaluation of [(18)F]ASEM in humans

PURPOSE: The α(7) nicotinic acetylcholine receptor (nAChR) is implicated in many neuropsychiatric disorders, making it an important target for positron emission tomography (PET) imaging. The first aim of this work was to compare two α(7) nAChRs PET radioligands, [(18)F]ASEM (3-(1,4-diazabicyclo[3.2....

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Detalhes bibliográficos
Publicado no:Eur J Nucl Med Mol Imaging
Main Authors: Hillmer, Ansel T., Li, Songye, Zheng, Ming-Qiang, Scheunemann, Matthias, Lin, Shu-fei, Nabulsi, Nabeel, Holden, Daniel, Pracitto, Richard, Labaree, David, Ropchan, Jim, Teodoro, Rodrigo, Deuther-Conrad, Winnie, Esterlis, Irina, Cosgrove, Kelly P., Brust, Peter, Carson, Richard E., Huang, Yiyun
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400702/
https://ncbi.nlm.nih.gov/pubmed/28120003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-017-3621-8
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