PET Imaging of α(7) Nicotinic Acetylcholine Receptors: A comparative study of [(18)F]ASEM and [(18)F]DBT-10 in non-human primates, and further evaluation of [(18)F]ASEM in humans

PURPOSE: The α(7) nicotinic acetylcholine receptor (nAChR) is implicated in many neuropsychiatric disorders, making it an important target for positron emission tomography (PET) imaging. The first aim of this work was to compare two α(7) nAChRs PET radioligands, [(18)F]ASEM (3-(1,4-diazabicyclo[3.2....

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izdano v:Eur J Nucl Med Mol Imaging
Main Authors: Hillmer, Ansel T., Li, Songye, Zheng, Ming-Qiang, Scheunemann, Matthias, Lin, Shu-fei, Nabulsi, Nabeel, Holden, Daniel, Pracitto, Richard, Labaree, David, Ropchan, Jim, Teodoro, Rodrigo, Deuther-Conrad, Winnie, Esterlis, Irina, Cosgrove, Kelly P., Brust, Peter, Carson, Richard E., Huang, Yiyun
Format: Artigo
Jezik:Inglês
Izdano: 2017
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5400702/
https://ncbi.nlm.nih.gov/pubmed/28120003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00259-017-3621-8
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