Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold

Autor Baumeister, Sören, Schepmann, Dirk, Wünsch, Bernhard
Vydáno v Medchemcomm (2019)

Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

Autor Bergkemper, Melanie, Schepmann, Dirk, Wünsch, Bernhard
Vydáno v ChemMedChem (2021)

Synthesis and σ receptor affinity of spiro[[2]benzopyran-1,1′-cyclohexanes] with an exocyclic amino moiety in the 3′-position

Autor Kronenberg, Elisabeth, Weber, Frauke, Schepmann, Dirk, Wünsch, Bernhard
Vydáno v RSC Med Chem (2020)

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

Autor Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard
Vydáno v Medchemcomm (2017)

Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity

Autor Torres-Gómez, Héctor, Daniliuc, Constantin, Schepmann, Dirk, Laurini, Erik, Pricl, Sabrina, Wünsch, Bernhard
Vydáno v Int J Mol Sci (2021)

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB(2) ligands by regioisomeric 1,3,4-oxadiazole ring

Autor Heimann, Dominik, Lueg, Corinna, de Vries, Henk, Frehland, Bastian, Schepmann, Dirk, Heitman, Laura H., Wünsch, Bernhard
Vydáno v Medchemcomm (2017)

Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

Autor Martin, Benedikt, Schepmann, Dirk, Bernal, Freddy A., Schmidt, Thomas J., Che, Tao, Loser, Karin, Wünsch, Bernhard
Vydáno v ChemMedChem (2020)

Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands

Autor Zampieri, Daniele, Fortuna, Sara, Calabretti, Antonella, Romano, Maurizio, Menegazzi, Renzo, Schepmann, Dirk, Wünsch, Bernhard, Mamolo, Maria Grazia
Vydáno v ACS Med Chem Lett (2019)

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ(1) Receptors in the Brain

Autor Holl, Katharina, Schepmann, Dirk, Fischer, Steffen, Ludwig, Friedrich-Alexander, Hiller, Achim, Donat, Cornelius K., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard
Vydáno 2014

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

Autor Schreiber, Julian A., Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard
Vydáno v Commun Biol (2019)

Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

Autor Tangherlini, Giovanni, Börgel, Frederik, Schepmann, Dirk, Slocum, Samuel, Che, Tao, Wagner, Stefan, Schwegmann, Katrin, Hermann, Sven, Mykicki, Nadine, Loser, Karin, Wünsch, Bernhard
Vydáno v ChemMedChem (2020)

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant (18)F-Labelled σ(2) Receptor Ligand

Autor Moldovan, Rareş-Petru, Gündel, Daniel, Teodoro, Rodrigo, Ludwig, Friedrich-Alexander, Fischer, Steffen, Toussaint, Magali, Schepmann, Dirk, Wünsch, Bernhard, Brust, Peter, Deuther-Conrad, Winnie
Vydáno v Int J Mol Sci (2021)

Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R)

Autor Rossino, Giacomo, Rui, Marta, Pozzetti, Luca, Schepmann, Dirk, Wünsch, Bernhard, Zampieri, Daniele, Pellavio, Giorgia, Laforenza, Umberto, Rinaldi, Silvia, Colombo, Giorgio, Morelli, Laura, Linciano, Pasquale, Rossi, Daniela, Collina, Simona
Vydáno v Int J Mol Sci (2020)

Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

Autor Cifani, Carlo, Micioni Di Bonaventura, Emanuela, Botticelli, Luca, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Piergentili, Alessandro, Quaglia, Wilma, Bonifazi, Alessandro, Schepmann, Dirk, Wünsch, Bernhard, Vistoli, Giulio, Micioni Di Bonaventura, Maria Vittoria
Vydáno v ACS Chem Neurosci (2020)

In vitro and in vivo Human Metabolism of (S)-[(18)F]Fluspidine – A Radioligand for Imaging σ(1) Receptors With Positron Emission Tomography (PET)

Autor Ludwig, Friedrich-Alexander, Fischer, Steffen, Houska, Richard, Hoepping, Alexander, Deuther-Conrad, Winnie, Schepmann, Dirk, Patt, Marianne, Meyer, Philipp M., Hesse, Swen, Becker, Georg-Alexander, Zientek, Franziska Ruth, Steinbach, Jörg, Wünsch, Bernhard, Sabri, Osama, Brust, Peter
Vydáno v Front Pharmacol (2019)

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells

Autor Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Santoni, Giorgio, Wünsch, Bernhard, Schepmann, Dirk, Cimarelli, Cristina, Pellei, Maura, Santini, Carlo, Fontana, Stefano, Mammoli, Valerio, Quaglia, Wilma, Bonifazi, Alessandro, Giannella, Mario, Giorgioni, Gianfabio, Piergentili, Alessandro, Del Bello, Fabio
Vydáno v ACS Med Chem Lett (2019)

Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors

Autor Wagner, Stefan, de Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna
Vydáno v ChemMedChem (2020)