Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold

بواسطة Baumeister, Sören, Schepmann, Dirk, Wünsch, Bernhard
الحاوية / القاعدة Medchemcomm (2019)

Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

بواسطة Bergkemper, Melanie, Schepmann, Dirk, Wünsch, Bernhard
الحاوية / القاعدة ChemMedChem (2021)

Synthesis and σ receptor affinity of spiro[[2]benzopyran-1,1′-cyclohexanes] with an exocyclic amino moiety in the 3′-position

بواسطة Kronenberg, Elisabeth, Weber, Frauke, Schepmann, Dirk, Wünsch, Bernhard
الحاوية / القاعدة RSC Med Chem (2020)

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

بواسطة Shuto, Yoshihiro, Thum, Simone, Temme, Louisa, Schepmann, Dirk, Kitamura, Masato, Wünsch, Bernhard
الحاوية / القاعدة Medchemcomm (2017)

Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity

بواسطة Torres-Gómez, Héctor, Daniliuc, Constantin, Schepmann, Dirk, Laurini, Erik, Pricl, Sabrina, Wünsch, Bernhard
الحاوية / القاعدة Int J Mol Sci (2021)

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB(2) ligands by regioisomeric 1,3,4-oxadiazole ring

بواسطة Heimann, Dominik, Lueg, Corinna, de Vries, Henk, Frehland, Bastian, Schepmann, Dirk, Heitman, Laura H., Wünsch, Bernhard
الحاوية / القاعدة Medchemcomm (2017)

Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

بواسطة Martin, Benedikt, Schepmann, Dirk, Bernal, Freddy A., Schmidt, Thomas J., Che, Tao, Loser, Karin, Wünsch, Bernhard
الحاوية / القاعدة ChemMedChem (2020)

Synthesis, Cytotoxicity Evaluation, and Computational Insights of Novel 1,4-Diazepane-Based Sigma Ligands

بواسطة Zampieri, Daniele, Fortuna, Sara, Calabretti, Antonella, Romano, Maurizio, Menegazzi, Renzo, Schepmann, Dirk, Wünsch, Bernhard, Mamolo, Maria Grazia
الحاوية / القاعدة ACS Med Chem Lett (2019)

Asymmetric Synthesis of Spirocyclic 2-Benzopyrans for Positron Emission Tomography of σ(1) Receptors in the Brain

بواسطة Holl, Katharina, Schepmann, Dirk, Fischer, Steffen, Ludwig, Friedrich-Alexander, Hiller, Achim, Donat, Cornelius K., Deuther-Conrad, Winnie, Brust, Peter, Wünsch, Bernhard
منشور في 2014

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

بواسطة Schreiber, Julian A., Schepmann, Dirk, Frehland, Bastian, Thum, Simone, Datunashvili, Maia, Budde, Thomas, Hollmann, Michael, Strutz-Seebohm, Nathalie, Wünsch, Bernhard, Seebohm, Guiscard
الحاوية / القاعدة Commun Biol (2019)

Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

بواسطة Tangherlini, Giovanni, Börgel, Frederik, Schepmann, Dirk, Slocum, Samuel, Che, Tao, Wagner, Stefan, Schwegmann, Katrin, Hermann, Sven, Mykicki, Nadine, Loser, Karin, Wünsch, Bernhard
الحاوية / القاعدة ChemMedChem (2020)

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant (18)F-Labelled σ(2) Receptor Ligand

بواسطة Moldovan, Rareş-Petru, Gündel, Daniel, Teodoro, Rodrigo, Ludwig, Friedrich-Alexander, Fischer, Steffen, Toussaint, Magali, Schepmann, Dirk, Wünsch, Bernhard, Brust, Peter, Deuther-Conrad, Winnie
الحاوية / القاعدة Int J Mol Sci (2021)

Setup and Validation of a Reliable Docking Protocol for the Development of Neuroprotective Agents by Targeting the Sigma-1 Receptor (S1R)

بواسطة Rossino, Giacomo, Rui, Marta, Pozzetti, Luca, Schepmann, Dirk, Wünsch, Bernhard, Zampieri, Daniele, Pellavio, Giorgia, Laforenza, Umberto, Rinaldi, Silvia, Colombo, Giorgio, Morelli, Laura, Linciano, Pasquale, Rossi, Daniela, Collina, Simona
الحاوية / القاعدة Int J Mol Sci (2020)

Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

بواسطة Cifani, Carlo, Micioni Di Bonaventura, Emanuela, Botticelli, Luca, Del Bello, Fabio, Giorgioni, Gianfabio, Pavletić, Pegi, Piergentili, Alessandro, Quaglia, Wilma, Bonifazi, Alessandro, Schepmann, Dirk, Wünsch, Bernhard, Vistoli, Giulio, Micioni Di Bonaventura, Maria Vittoria
الحاوية / القاعدة ACS Chem Neurosci (2020)

In vitro and in vivo Human Metabolism of (S)-[(18)F]Fluspidine – A Radioligand for Imaging σ(1) Receptors With Positron Emission Tomography (PET)

بواسطة Ludwig, Friedrich-Alexander, Fischer, Steffen, Houska, Richard, Hoepping, Alexander, Deuther-Conrad, Winnie, Schepmann, Dirk, Patt, Marianne, Meyer, Philipp M., Hesse, Swen, Becker, Georg-Alexander, Zientek, Franziska Ruth, Steinbach, Jörg, Wünsch, Bernhard, Sabri, Osama, Brust, Peter
الحاوية / القاعدة Front Pharmacol (2019)

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells

بواسطة Morelli, Maria Beatrice, Amantini, Consuelo, Nabissi, Massimo, Santoni, Giorgio, Wünsch, Bernhard, Schepmann, Dirk, Cimarelli, Cristina, Pellei, Maura, Santini, Carlo, Fontana, Stefano, Mammoli, Valerio, Quaglia, Wilma, Bonifazi, Alessandro, Giannella, Mario, Giorgioni, Gianfabio, Piergentili, Alessandro, Del Bello, Fabio
الحاوية / القاعدة ACS Med Chem Lett (2019)

Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors

بواسطة Wagner, Stefan, de Moura Gatti, Fernando, Silva, Daniel G., Ortiz Zacarias, Natalia V., Zweemer, Annelien J. M., Hermann, Sven, De Maria, Monica, Koch, Michael, Weiss, Christina, Schepmann, Dirk, Heitman, Laura H., Tschammer, Nuska, Kopka, Klaus, Junker, Anna
الحاوية / القاعدة ChemMedChem (2020)