Chimeric mice with humanized liver as a model for testing organophosphate and carbamate pesticide exposure

Por Suemizu, Hiroshi, Kawai, Kenji, Murayama, Norie, Nakamura, Masato, Yamazaki, Hiroshi
Publicado no Pest Manag Sci (2018)

Combining Chimeric Mice with Humanized Liver, Mass Spectrometry, And Physiologically-Based Pharmacokinetic Modeling in Toxicology

Por Yamazaki, Hiroshi, Suemizu, Hiroshi, Mitsui, Marina, Shimizu, Makiko, Guengerich, F. Peter
Publicado no Chem Res Toxicol (2016)

Simulation of Human Plasma Concentrations of Thalidomide and Primary 5-Hydroxylated Metabolites Explored with Pharmacokinetic Data in Humanized TK-NOG mice

Por Nishiyama, Sayako, Suemizu, Hiroshi, Shibata, Norio, Guengerich, F. Peter, Yamazaki, Hiroshi
Publicado no Chem Res Toxicol (2015)

Metabolic Profiles of Pomalidomide in Human Plasma Simulated with Pharmacokinetic Data in Control and Humanized-liver Mice

Por Shimizu, Makiko, Suemizu, Hiroshi, Mitsui, Marina, Shibata, Norio, Guengerich, F. Peter, Yamazaki, Hiroshi
Publicado no Xenobiotica (2016)

A basolateral sorting motif in the MICA cytoplasmic tail

Por Suemizu, Hiroshi, Radosavljevic, Mirjana, Kimura, Minoru, Sadahiro, Sotaro, Yoshimura, Shinichi, Bahram, Seiamak, Inoko, Hidetoshi
Publicado em 2002

Targeted sequencing reveals genetic variants associated with sensitivity of 79 human cancer xenografts to anticancer drugs

Por Udagawa, Chihiro, Sasaki, Yasushi, Suemizu, Hiroshi, Ohnishi, Yasuyuki, Ohnishi, Hiroshi, Tokino, Takashi, Zembutsu, Hitoshi
Publicado no Exp Ther Med (2018)

Comparative Transcriptomics Analyses in Livers of Mice, Humans, and Humanized Mice Define Human-Specific Gene Networks

Por Jiang, Chengfei, Li, Ping, Ruan, Xiangbo, Ma, Yonghe, Kawai, Kenji, Suemizu, Hiroshi, Cao, Haiming
Publicado no Cells (2020)

The human hepatic cell line HepaRG as a possible cell source for the generation of humanized liver TK-NOG mice

Por Higuchi, Yuichiro, Kawai, Kenji, Yamazaki, Hiroshi, Nakamura, Masato, Bree, Françoise, Guguen-Guillouzo, Christiane, Suemizu, Hiroshi
Publicado em 2014

In vivo Drug Interactions of the Teratogen Thalidomide with Midazolam: Heterotropic Cooperativity of Human Cytochrome P450 in Humanized TK-NOG Mice

Por Yamazaki, Hiroshi, Suemizu, Hiroshi, Murayama, Norie, Utoh, Masahiro, Shibata, Norio, Nakamura, Masato, Guengerich, F. Peter
Publicado em 2013

A Versatile Technique for the In Vivo Imaging of Human Tumor Xenografts Using Near-Infrared Fluorochrome-Conjugated Macromolecule Probes

Por Suemizu, Hiroshi, Kawai, Kenji, Higuchi, Yuichiro, Hashimoto, Haruo, Ogura, Tomoyuki, Itoh, Toshio, Sasaki, Erika, Nakamura, Masato
Publicado em 2013

A Novel Enhanced Green FluorescentProtein-Expressing NOG Mouse for Analyzingthe Microenvironment of Xenograft Tissues

Por Higuchi, Yuichiro, Kawai, Kenji, Yamamoto, Masahumi, Kuronuma, Miyuki, Ando, Yasuhiko, Katano, Ikumi, Nakamura, Masato, Suemizu, Hiroshi
Publicado em 2014

Hepatocytes buried in the cirrhotic livers of patients with biliary atresia proliferate and function in the livers of urokinase-type plasminogen activator–NOG mice

Por Suemizu, Hiroshi, Nakamura, Kazuaki, Kawai, Kenji, Higuchi, Yuichiro, Kasahara, Mureo, Fujimoto, Junichiro, Tanoue, Akito, Nakamura, Masato
Publicado no Liver Transpl (2014)

Whole-exome sequencing of 79 xenografts as a potential approach for the identification of genetic variants associated with sensitivity to cytotoxic anticancer drugs

Por Udagawa, Chihiro, Sasaki, Yasushi, Tanizawa, Yasuhiro, Suemizu, Hiroshi, Ohnishi, Yasuyuki, Nakamura, Yasukazu, Tokino, Takashi, Zembutsu, Hitoshi
Publicado no PLoS One (2020)

In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice

Por Yamazaki, Hiroshi, Suemizu, Hiroshi, Igaya, Sho, Shimizu, Makiko, Shibata, Norio, Nakamura, Masato, Chowdhury, Goutam, Guengerich, F. Peter
Publicado em 2011

In vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG mice

Por Yamazaki, Hiroshi, Suemizu, Hiroshi, Shimizu, Makiko, Igaya, Sho, Shibata, Norio, Nakamura, Masato, Chowdhury, Goutam, Guengerich, F. Peter
Publicado em 2012

Expression of pancreatic and duodenal homeobox1 (PDX1) protein in the interior and exterior regions of the intestine, revealed by development and analysis of Pdx1 knockout mice

Por Hashimoto, Haruo, Kamisako, Tsutomu, Kagawa, Takahiro, Haraguchi, Seiki, Yagoto, Mika, Takahashi, Ri-ichi, Kawai, Kenji, Suemizu, Hiroshi
Publicado no Lab Anim Res (2015)

ATP7B expression is associated with in vitro sensitivity to cisplatin in non-small cell lung cancer

Por INOUE, YOSHIMASA, MATSUMOTO, HOZUMI, YAMADA, SHUNSUKE, KAWAI, KENJI, SUEMIZU, HIROSHI, GIKA, MASATOSHI, TAKANAMI, IWAO, NAKAMURA, MASATO, IWAZAKI, MASAYUKI
Publicado em 2010

Association of ATP7A expression and in vitro sensitivity to cisplatin in non-small cell lung cancer

Por INOUE, YOSHIMASA, MATSUMOTO, HOZUMI, YAMADA, SHUNSUKE, KAWAI, KENJI, SUEMIZU, HIROSHI, GIKA, MASATOSHI, TAKANAMI, IWAO, IWAZAKI, MASAYUKI, NAKAMURA, MASATO
Publicado em 2010

Generation of Human Immunosuppressive Myeloid Cell Populations in Human Interleukin-6 Transgenic NOG Mice

Por Hanazawa, Asami, Ito, Ryoji, Katano, Ikumi, Kawai, Kenji, Goto, Motohito, Suemizu, Hiroshi, Kawakami, Yutaka, Ito, Mamoru, Takahashi, Takeshi
Publicado no Front Immunol (2018)

The Adult Livers of Immunodeficient Mice Support Human Hematopoiesis: Evidence for a Hepatic Mast Cell Population that Develops Early in Human Ontogeny

Por Muench, Marcus O., Beyer, Ashley I., Fomin, Marina E., Thakker, Rahul, Mulvaney, Usha S., Nakamura, Masato, Suemizu, Hiroshi, Bárcena, Alicia
Publicado em 2014