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Metabolic Profiles of Pomalidomide in Human Plasma Simulated with Pharmacokinetic Data in Control and Humanized-liver Mice
1. Pomalidomide has been shown to be potentially teratogenic in thalidomide-sensitive animal species such as rabbits. Screening for thalidomide analogs devoid of teratogenicity/toxicity—attributable to metabolites formed by cytochrome P450 enzymes—but having immunomodulatory properties is a strategi...
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| Publicado no: | Xenobiotica |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5433912/ https://ncbi.nlm.nih.gov/pubmed/27852146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/00498254.2016.1247218 |
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