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In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice
Metabolism of the teratogen thalidomide is proposed to be relevant to its toxicological action. We demonstrated formation of the glutathione (GSH) conjugate of (R)-5-hydroxythalidomide in vivo in chimeric NOD-scid IL2Rg(null) mice with humanized liver (uPA-NOG mice). After an oral administration of...
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| Autores principales: | , , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2011
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3838788/ https://ncbi.nlm.nih.gov/pubmed/21299192 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200005g |
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