In Vivo Formation of a Glutathione Conjugate Derived from Thalidomide in Humanized uPA-NOG Mice

Metabolism of the teratogen thalidomide is proposed to be relevant to its toxicological action. We demonstrated formation of the glutathione (GSH) conjugate of (R)-5-hydroxythalidomide in vivo in chimeric NOD-scid IL2Rg(null) mice with humanized liver (uPA-NOG mice). After an oral administration of...

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Hauptverfasser: Yamazaki, Hiroshi, Suemizu, Hiroshi, Igaya, Sho, Shimizu, Makiko, Shibata, Norio, Nakamura, Masato, Chowdhury, Goutam, Guengerich, F. Peter
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3838788/
https://ncbi.nlm.nih.gov/pubmed/21299192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200005g
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