In vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG mice

The formation of dihydroxythalidomide and glutathione (GSH) conjugate(s) of 5-hydroxythalidomide were investigated in chimeric mice modified with “humanized” liver: novel humanized TK-NOG mice were prepared by introduction of thymidine kinase, followed by induction with ganciclovir, and human liver...

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Hlavní autoři: Yamazaki, Hiroshi, Suemizu, Hiroshi, Shimizu, Makiko, Igaya, Sho, Shibata, Norio, Nakamura, Masato, Chowdhury, Goutam, Guengerich, F. Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3976424/
https://ncbi.nlm.nih.gov/pubmed/22268628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300009j
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