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In vivo Formation of Dihydroxylated and Glutathione Conjugate Metabolites derived from Thalidomide and 5-Hydroxythalidomide in Humanized TK-NOG mice
The formation of dihydroxythalidomide and glutathione (GSH) conjugate(s) of 5-hydroxythalidomide were investigated in chimeric mice modified with “humanized” liver: novel humanized TK-NOG mice were prepared by introduction of thymidine kinase, followed by induction with ganciclovir, and human liver...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3976424/ https://ncbi.nlm.nih.gov/pubmed/22268628 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx300009j |
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