Delineation of a Fundamental α-Ketoheterocycle Substituent Effect For Use in the Design of Enzyme Inhibitors

le Romero, F. Anthony, Hwang, Inkyu, Boger, Dale L.
Foilsithe 2006

Total Synthesis of Piericidin A1 and B1 and Key Analogues

le Schnermann, Martin J., Romero, F. Anthony, Hwang, Inkyu, Nakamaru-Ogiso, Eiko, Yagi, Takao, Boger, Dale L.
Foilsithe 2006

Structure–Activity Relationships of α-Keto Oxazole Inhibitors of Fatty Acid Amide Hydrolase

le Hardouin, Christophe, Kelso, Michael J., Romero, F. Anthony, Rayl, Thomas J., Leung, Donmienne, Hwang, Inkyu, Cravatt, Benjamin F., Boger, Dale L.
Foilsithe 2007

Optimization of α-Ketooxazole Inhibitors of Fatty Acid Amide Hydrolase

le Kimball, F. Scott, Romero, F. Anthony, Ezzili, Cyrine, Garfunkle, Joie, Rayl, Thomas J., Hochstatter, Dustin G., Hwang, Inkyu, Boger, Dale L.
Foilsithe 2008

Potent and Selective α-Ketoheterocycle-Based Inhibitors of the Anandamide and Oleamide Catabolizing Enzyme, Fatty Acid Amide Hydrolase

le Romero, F. Anthony, Du, Wu, Hwang, Inkyu, Rayl, Thomas J., Kimball, F. Scott, Leung, Donmienne, Hoover, Heather S., Apodaca, Richard L., Breitenbucher, J. Guy, Cravatt, Benjamin F., Boger, Dale L.
Foilsithe 2007

Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5-Selective Antagonists

le Liu, Weiguo, Hussain, Zahid, Zang, Yi, Sweis, Ramzi F., Romero, F. Anthony, Finke, Paul E., Moningka, Remond, Bao, Jianming, Plotkin, Michael A., Shang, Jin, Dingley, Karen H., Salituro, Gino, Murphy, Beth Ann, Howard, Andrew D., Ujjainwalla, Feroze, Wood, Harold B., Duffy, Joseph L.
Foilsithe in ACS Med Chem Lett (2018)

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase

le Feng, Danqing, Biftu, Tesfaye, Romero, F. Anthony, Kekec, Ahmet, Dropinski, James, Kassick, Andrew, Xu, Shiyao, Kurtz, Marc M., Gollapudi, Anantha, Shao, Qing, Yang, Xiaodong, Lu, Ku, Zhou, Gaochao, Kemp, Daniel, Myers, Robert W., Guan, Hong-Ping, Trujillo, Maria E., Li, Cai, Weber, Ann, Sebhat, Iyassu K.
Foilsithe in ACS Med Chem Lett (2017)

GNE-886: A Potent and Selective Inhibitor of the Cat Eye Syndrome Chromosome Region Candidate 2 Bromodomain (CECR2)

le Crawford, Terry D., Audia, James E., Bellon, Steve, Burdick, Daniel J., Bommi-Reddy, Archana, Côté, Alexandre, Cummings, Richard T., Duplessis, Martin, Flynn, E. Megan, Hewitt, Michael, Huang, Hon-Ren, Jayaram, Hariharan, Jiang, Ying, Joshi, Shivangi, Kiefer, James R., Murray, Jeremy, Nasveschuk, Christopher G., Neiss, Arianne, Pardo, Eneida, Romero, F. Anthony, Sandy, Peter, Sims, Robert J., Tang, Yong, Taylor, Alexander M., Tsui, Vickie, Wang, Jian, Wang, Shumei, Wang, Yongyun, Xu, Zhaowu, Zawadzke, Laura, Zhu, Xiaoqin, Albrecht, Brian K., Magnuson, Steven R., Cochran, Andrea G.
Foilsithe in ACS Med Chem Lett (2017)

Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition

le Ghosh, Srimoyee, Taylor, Alexander, Chin, Melissa, Huang, Hon-Ren, Conery, Andrew R., Mertz, Jennifer A., Salmeron, Andres, Dakle, Pranal J., Mele, Deanna, Cote, Alexandre, Jayaram, Hari, Setser, Jeremy W., Poy, Florence, Hatzivassiliou, Georgia, DeAlmeida-Nagata, Denise, Sandy, Peter, Hatton, Charlie, Romero, F. Anthony, Chiang, Eugene, Reimer, Thornik, Crawford, Terry, Pardo, Eneida, Watson, Venita G., Tsui, Vickie, Cochran, Andrea G., Zawadzke, Laura, Harmange, Jean-Christophe, Audia, James E., Bryant, Barbara M., Cummings, Richard T., Magnuson, Steven R., Grogan, Jane L., Bellon, Steve F., Albrecht, Brian K., Sims, Robert J., Lora, Jose M.
Foilsithe in J Biol Chem (2016)

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

le Taylor, Alexander M., Côté, Alexandre, Hewitt, Michael C., Pastor, Richard, Leblanc, Yves, Nasveschuk, Christopher G., Romero, F. Anthony, Crawford, Terry D., Cantone, Nico, Jayaram, Hariharan, Setser, Jeremy, Murray, Jeremy, Beresini, Maureen H., de Leon Boenig, Gladys, Chen, Zhongguo, Conery, Andrew R., Cummings, Richard T., Dakin, Leslie A., Flynn, E. Megan, Huang, Oscar W., Kaufman, Susan, Keller, Patricia J., Kiefer, James R., Lai, Tommy, Li, Yingjie, Liao, Jiangpeng, Liu, Wenfeng, Lu, Henry, Pardo, Eneida, Tsui, Vickie, Wang, Jian, Wang, Yongyun, Xu, Zhaowu, Yan, Fen, Yu, Dong, Zawadzke, Laura, Zhu, Xiaoqin, Zhu, Xiaoyu, Sims, Robert J., Cochran, Andrea G., Bellon, Steve, Audia, James E., Magnuson, Steven, Albrecht, Brian K.
Foilsithe in ACS Med Chem Lett (2016)