Allosteric Modulators of GABA(B) Receptors: Mechanism of Action and Therapeutic Perspective

Por Pin, Jean-Philippe, Prézeau, Laurent
Publicado em 2007

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14

Por Lahaie, Nicolas, Kralikova, Michaela, Prézeau, Laurent, Blahos, Jaroslav, Bouvier, Michel
Publicado no J Biol Chem (2016)

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor

Por Binet, Virginie, Brajon, Carole, Le Corre, Laurent, Acher, Francine, Pin, Jean-Philippe, Prézeau, Laurent
Publicado em 2004

A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(b) receptor

Por Duthey, Béatrice, Caudron, Sara, Perroy, Julie, Bettler, Bernhard, Fagni, Laurent, Pin, Jean-Philippe, Prézeau, Laurent
Publicado em 2002

Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function

Por Galvez, Thierry, Duthey, Béatrice, Kniazeff, Julie, Blahos, Jaroslav, Rovelli, Giorgio, Bettler, Bernhard, Prézeau, Laurent, Pin, Jean-Philippe
Publicado em 2001

Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors

Por Binet, Virginie, Duthey, Béatrice, Lecaillon, Jennifer, Vol, Claire, Quoyer, Julie, Labesse, Gilles, Pin, Jean-Philippe, Prézeau, Laurent
Publicado em 2007

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists

Por Bessis, Anne-Sophie, Rondard, Philippe, Gaven, Florence, Brabet, Isabelle, Triballeau, Nicolas, Prézeau, Laurent, Acher, Francine, Pin, Jean-Philippe
Publicado em 2002

The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II Displays Structural and Functional Chemokine Features

Por Castel, Hélène, Desrues, Laurence, Joubert, Jane-Eileen, Tonon, Marie-Christine, Prézeau, Laurent, Chabbert, Marie, Morin, Fabrice, Gandolfo, Pierrick
Publicado no Front Endocrinol (Lausanne) (2017)

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators

Por Goudet, Cyril, Kniazeff, Julie, Hlavackova, Veronika, Malhaire, Fanny, Maurel, Damien, Acher, Francine, Blahos, Jaroslav, Prézeau, Laurent, Pin, Jean-Philippe
Publicado em 2005

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors

Por Goudet, Cyril, Gaven, Florence, Kniazeff, Julie, Vol, Claire, Liu, Jiangfeng, Cohen-Gonsaud, Martin, Acher, Francine, Prézeau, Laurent, Pin, Jean Philippe
Publicado em 2004

Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR

Por Hlavackova, Veronika, Goudet, Cyril, Kniazeff, Julie, Zikova, Alice, Maurel, Damien, Vol, Claire, Trojanova, Johana, Prézeau, Laurent, Pin, Jean-Philippe, Blahos, Jaroslav
Publicado em 2005

Crosstalk between GABA(B) and mGlu1a receptors reveals new insight into GPCR signal integration

Por Rives, Marie-Laure, Vol, Claire, Fukazawa, Yugo, Tinel, Norbert, Trinquet, Eric, Ayoub, Mohammed Akli, Shigemoto, Ryuichi, Pin, Jean-Philippe, Prézeau, Laurent
Publicado em 2009

Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser(280) by Hallucinogenic versus Nonhallucinogenic Agonists

Por Karaki, Samah, Becamel, Carine, Murat, Samy, Mannoury la Cour, Clotilde, Millan, Mark J., Prézeau, Laurent, Bockaert, Joël, Marin, Philippe, Vandermoere, Franck
Publicado em 2014

Metabotropic Glutamate Receptor 1 Splice Variants mGluR1a and mGluR1b Combine in mGluR1a/b Dimers in vivo

Por Techlovská, Šárka, Chambers, Jayne Nicole, Dvořáková, Michaela, Petralia, Ronald S., Wang, Ya-Xian, Hájková, Alena, Nová, Alice, Franková, Daniela, Prezeau, Laurent, Blahos, Jaroslav
Publicado em 2014

Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling

Por Zindel, Diana, Engel, Sandra, Bottrill, Andrew R., Pin, Jean-Philippe, Prézeau, Laurent, Tobin, Andrew B., Bünemann, Moritz, Krasel, Cornelius, Butcher, Adrian J.
Publicado no Biochem J (2016)

Up-regulation of GABA(B) Receptor Signaling by Constitutive Assembly with the K(+) Channel Tetramerization Domain-containing Protein 12 (KCTD12)

Por Ivankova, Klara, Turecek, Rostislav, Fritzius, Thorsten, Seddik, Riad, Prezeau, Laurent, Comps-Agrar, Laëtitia, Pin, Jean-Philippe, Fakler, Bernd, Besseyrias, Valerie, Gassmann, Martin, Bettler, Bernhard
Publicado em 2013

The oligomeric state sets GABA(B) receptor signalling efficacy

Por Comps-Agrar, Laëtitia, Kniazeff, Julie, Nørskov-Lauritsen, Lenea, Maurel, Damien, Gassmann, Martin, Gregor, Nathalie, Prézeau, Laurent, Bettler, Bernhard, Durroux, Thierry, Trinquet, Eric, Pin, Jean-Philippe
Publicado em 2011

A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate

Por Levoye, Angélique, Zwier, Jurriaan M., Jaracz-Ros, Agnieszka, Klipfel, Laurence, Cottet, Martin, Maurel, Damien, Bdioui, Sara, Balabanian, Karl, Prézeau, Laurent, Trinquet, Eric, Durroux, Thierry, Bachelerie, Françoise
Publicado no Front Endocrinol (Lausanne) (2015)

Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics

Por Møller, Thor C., Hottin, Jerome, Clerté, Caroline, Zwier, Jurriaan M., Durroux, Thierry, Rondard, Philippe, Prézeau, Laurent, Royer, Catherine A., Pin, Jean-Philippe, Margeat, Emmanuel, Kniazeff, Julie
Publicado no Sci Rep (2018)

BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity

Por Carroll, Fiona Y., Stolle, Andreas, Beart, Philip M., Voerste, Arnd, Brabet, Isabelle, Mauler, Frank, Joly, Cécile, Antonicek, Horst, Bockaert, Joël, Müller, Thomas, Pin, Jean-Philippe, Prézeau, Laurent
Publicado em 2001