Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators

The recent discovery of positive allosteric modulators (PAMs) for G-protein coupled receptors (GPCRs) open new possibilities to control a number of physiological and pathological processes. Understanding the mechanism of action of such compounds will provide new information on the activation process...

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Autores principales: Goudet, Cyril, Kniazeff, Julie, Hlavackova, Veronika, Malhaire, Fanny, Maurel, Damien, Acher, Francine, Blahos, Jaroslav, Prézeau, Laurent, Pin, Jean-Philippe
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2005
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2557058/
https://ncbi.nlm.nih.gov/pubmed/15863499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M502642200
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