Quantitative Phosphoproteomics Unravels Biased Phosphorylation of Serotonin 2A Receptor at Ser(280) by Hallucinogenic versus Nonhallucinogenic Agonists

The serotonin 5-HT(2A) receptor is a primary target of psychedelic hallucinogens such as lysergic acid diethylamine, mescaline, and psilocybin, which reproduce some of the core symptoms of schizophrenia. An incompletely resolved paradox is that only some 5-HT(2A) receptor agonists exhibit hallucinog...

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Autors principals: Karaki, Samah, Becamel, Carine, Murat, Samy, Mannoury la Cour, Clotilde, Millan, Mark J., Prézeau, Laurent, Bockaert, Joël, Marin, Philippe, Vandermoere, Franck
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Biochemistry and Molecular Biology 2014
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4014284/
https://ncbi.nlm.nih.gov/pubmed/24637012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/mcp.M113.036558
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