A phase II study of combined therapy with a BRAF inhibitor (vemurafenib) and interleukin-2 (aldesleukin) in patients with metastatic melanoma

por Mooradian, Meghan J., Reuben, Alexandre, Prieto, Peter A., Hazar-Rethinam, Mehlika, Frederick, Dennie T., Nadres, Brandon, Piris, Adriano, Juneja, Vikram, Cooper, Zachary A., Sharpe, Arlene H., Corcoran, Ryan B., Flaherty, Keith T., Lawrence, Donald P., Wargo, Jennifer A., Sullivan, Ryan J.
Publicado en Oncoimmunology (2018)

Heterogeneity and Coexistence of T790M and T790 Wild-Type Resistant Subclones Drive Mixed Response to Third-Generation Epidermal Growth Factor Receptor Inhibitors in Lung Cancer

por Piotrowska, Zofia, Hazar-Rethinam, Mehlika, Rizzo, Coleen, Nadres, Brandon, Van Seventer, Emily E., Shahzade, Heather A., Lennes, Inga T., Iafrate, Anthony J., Dias-Santagata, Dora, Leshchiner, Ignaty, Jessop, Nicholas A., Hu, Haichuan, Digumarthy, Subba R., Nagy, Rebecca J., Lanman, Richard B., Moody, Susan, Niederst, Matthew J., Engelman, Jeffrey A., Hata, Aaron N., Corcoran, Ryan B., Sequist, Lecia V.
Publicado en JCO Precis Oncol (2018)

Convergent therapeutic strategies to overcome the heterogeneity of acquired resistance in BRAF(V600E) colorectal cancer

por Hazar-Rethinam, Mehlika, Kleyman, Marianna, Han, G. Celine, Liu, David, Ahronian, Leanne G., Shahzade, Heather A., Chen, Lifeng, Parikh, Aparna R., Allen, Jill N., Clark, Jeffrey W., Kwak, Eunice L., Faris, Jason E., Murphy, Janet E., Hong, Theodore S., Van Seventer, Emily E., Nadres, Brandon, Hong, Catriona B., Gurski, Joseph M., Jessop, Nicholas A., Dias-Santagata, Dora, Iafrate, A. John, Van Allen, Eliezer M., Corcoran, Ryan B.
Publicado en Cancer Discov (2018)

Co-occurring alterations in the RAS-MAPK pathway limit response to MET inhibitor treatment in MET exon 14 skipping mutation-positive lung cancer

por Rotow, Julia K., Gui, Philippe, Wu, Wei, Raymond, Victoria M., Lanman, Richard B., Kaye, Frederic J., Peled, Nir, Fece de la Cruz, Ferran, Nadres, Brandon, Corcoran, Ryan B., Yeh, Iwei, Bastian, Boris C., Starostik, Petr, Newsom, Kimberly, Olivas, Victor R., Wolff, Alexander M., Fraser, James S., Collisson, Eric A., McCoach, Caroline E., Camidge, D. Ross, Pacheco, Jose, Bazhenova, Lyudmila, Li, Tianhong, Bivona, Trever G., Blakely, Collin M.
Publicado en Clin Cancer Res (2019)

Circulating Tumor DNA Predicts Pathologic and Clinical Outcomes Following Neoadjuvant Chemoradiation and Surgery for Patients With Locally Advanced Rectal Cancer

por McDuff, Susan G. R., Hardiman, Karin M., Ulintz, Peter J., Parikh, Aparna R., Zheng, Hui, Kim, Daniel W., Lennerz, Jochen K., Hazar-Rethinam, Mehlika, Van Seventer, Emily E., Fetter, Isobel J., Nadres, Brandon, Eyler, Christine E., Ryan, David P., Weekes, Colin D., Clark, Jeffrey W., Cusack, James C., Goyal, Lipika, Zhu, Andrew X., Wo, Jennifer Y., Blaszkowsky, Lawrence S., Allen, Jill, Corcoran, Ryan B., Hong, Theodore S.
Publicado en JCO Precis Oncol (2021)

Serial ctDNA monitoring to predict response to systemic therapy in metastatic gastrointestinal cancers

por Parikh, Aparna R., Mojtahed, Amikasra, Schneider, Jaime L., Kanter, Katie, van Seventer, Emily E., Fetter, Isobel J., Thabet, Ashraf, Fish, Madeleine G., Teshome, Bezaye, Fosbenner, Kathryn D., Nadres, Brandon, Shahzade, Heather, Allen, Jill N., Blaszkowsky, Lawrence S., Ryan, David P., Giantonio, Bruce J., Goyal, Lipika, Nipp, Ryan D., Roeland, Eric, Weekes, Colin D., Wo, Jennifer Y., Zhu, Andrew X., Dias-Santagata, Dora, Iafrate, A. John, Lennerz, Jochen K, Hong, Theodore S., Siravegna, Giulia, Horick, Nora, Clark, Jeffrey W., Corcoran, Ryan B.
Publicado en Clin Cancer Res (2020)

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

por Sade-Feldman, Moshe, Jiao, Yunxin J., Chen, Jonathan H., Rooney, Michael S., Barzily-Rokni, Michal, Eliane, Jean-Pierre, Bjorgaard, Stacey L., Hammond, Marc R., Vitzthum, Hans, Blackmon, Shauna M., Frederick, Dennie T., Hazar-Rethinam, Mehlika, Nadres, Brandon A., Van Seventer, Emily E., Shukla, Sachet A., Yizhak, Keren, Ray, John P., Rosebrock, Daniel, Livitz, Dimitri, Adalsteinsson, Viktor, Getz, Gad, Duncan, Lyn M., Li, Bo, Corcoran, Ryan B., Lawrence, Donald P., Stemmer-Rachamimov, Anat, Boland, Genevieve M., Landau, Dan A., Flaherty, Keith T., Sullivan, Ryan J., Hacohen, Nir
Publicado en Nat Commun (2017)

TAS-120 overcomes resistance to ATP-competitive FGFR inhibitors in patients with FGFR2 fusion-positive intrahepatic cholangiocarcinoma

por Goyal, Lipika, Shi, Lei, Liu, Leah Y., de la Cruz, Ferran Fece, Lennerz, Jochen K., Raghavan, Srivatsan, Leschiner, Ignaty, Elagina, Liudmila, Siravegna, Giulia, Ng, Raymond W.S., Vu, Phuong, Patra, Krushna C., Saha, Supriya K., Uppot, Raul N., Arellano, Ron, Reyes, Stephanie, Sagara, Takeshi, Otsuki, Sachie, Nadres, Brandon, Shahzade, Heather A., Dey-Guha, Ipsita, Fetter, Isobel J., Baiev, Islam, Van Seventer, Emily E., Murphy, Janet E., Ferrone, Cristina R., Tanabe, Kenneth K., Deshpande, Vikram, Harding, James J., Yaeger, Rona, Kelley, Robin K., Bardelli, Alberto, Iafrate, A. John, Hahn, William C., Benes, Cyril H., Ting, David T., Hirai, Hiroshi, Getz, Gad, Juric, Dejan, Zhu, Andrew X., Corcoran, Ryan B., Bardeesy, Nabeel
Publicado en Cancer Discov (2019)

Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers

por Parikh, Aparna R., Leshchiner, Ignaty, Elagina, Liudmila, Goyal, Lipika, Levovitz, Chaya, Siravegna, Giulia, Livitz, Dimitri, Rhrissorrakrai, Kahn, Martin, Elizabeth E., Van Seventer, Emily E., Hanna, Megan, Slowik, Kara, Utro, Filippo, Pinto, Christopher J., Wong, Alicia, Danysh, Brian P., de la Cruz, Ferran Fece, Fetter, Isobel J., Nadres, Brandon, Shahzade, Heather A., Allen, Jill N., Blaszkowsky, Lawrence S., Clark, Jeffrey W., Giantonio, Bruce, Murphy, Janet E., Nipp, Ryan D., Roeland, Eric, Ryan, David P., Weekes, Colin D., Kwak, Eunice L., Faris, Jason E., Wo, Jennifer Y., Aguet, François, Dey-Guha, Ipsita, Hazar-Rethinam, Mehlika, Dias-Santagata, Dora, Ting, David T., Zhu, Andrew X., Hong, Theodore S., Golub, Todd R., Iafrate, A. John, Adalsteinsson, Viktor A., Bardelli, Alberto, Parida, Laxmi, Juric, Dejan, Getz, Gad, Corcoran, Ryan B.
Publicado en Nat Med (2019)

Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine

por Aguirre, Andrew J., Nowak, Jonathan A., Camarda, Nicholas D., Moffitt, Richard A., Ghazani, Arezou A., Hazar-Rethinam, Mehlika, Raghavan, Srivatsan, Kim, Jaegil, Brais, Lauren K., Ragon, Dorisanne, Welch, Marisa W., Reilly, Emma, McCabe, Devin, Marini, Lori, Anderka, Kristin, Helvie, Karla, Oliver, Nelly, Babic, Ana, Da Silva, Annacarolina, Nadres, Brandon, Van Seventer, Emily E., Shahzade, Heather A., St. Pierre, Joseph P., Burke, Kelly P., Clancy, Thomas, Cleary, James M., Doyle, Leona A., Jajoo, Kunal, McCleary, Nadine J., Meyerhardt, Jeffrey A., Murphy, Janet E., Ng, Kimmie, Patel, Anuj K., Perez, Kimberly, Rosenthal, Michael H., Rubinson, Douglas A., Ryou, Marvin, Shapiro, Geoffrey I., Sicinska, Ewa, Silverman, Stuart G., Nagy, Rebecca J., Lanman, Richard B., Knoerzer, Deborah, Welsch, Dean J., Yurgelun, Matthew B., Fuchs, Charles S., Garraway, Levi A., Getz, Gad, Hornick, Jason L., Johnson, Bruce E., Kulke, Matthew H., Mayer, Robert J., Miller, Jeffrey W., Shyn, Paul B., Tuveson, David A., Wagle, Nikhil, Yeh, Jen Jen, Hahn, William C., Corcoran, Ryan B., Carter, Scott L., Wolpin, Brian M.
Publicado en Cancer Discov (2018)