Real-time genomic characterization of advanced pancreatic cancer to enable precision medicine

Clinically relevant subtypes exist for pancreatic ductal adenocarcinoma (PDAC), but molecular characterization is not yet standard in clinical care. We implemented a biopsy protocol to perform time-sensitive whole exome sequencing and RNA-sequencing for patients with advanced PDAC. Therapeutically r...

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Vydáno v:Cancer Discov
Hlavní autoři: Aguirre, Andrew J., Nowak, Jonathan A., Camarda, Nicholas D., Moffitt, Richard A., Ghazani, Arezou A., Hazar-Rethinam, Mehlika, Raghavan, Srivatsan, Kim, Jaegil, Brais, Lauren K., Ragon, Dorisanne, Welch, Marisa W., Reilly, Emma, McCabe, Devin, Marini, Lori, Anderka, Kristin, Helvie, Karla, Oliver, Nelly, Babic, Ana, Da Silva, Annacarolina, Nadres, Brandon, Van Seventer, Emily E., Shahzade, Heather A., St. Pierre, Joseph P., Burke, Kelly P., Clancy, Thomas, Cleary, James M., Doyle, Leona A., Jajoo, Kunal, McCleary, Nadine J., Meyerhardt, Jeffrey A., Murphy, Janet E., Ng, Kimmie, Patel, Anuj K., Perez, Kimberly, Rosenthal, Michael H., Rubinson, Douglas A., Ryou, Marvin, Shapiro, Geoffrey I., Sicinska, Ewa, Silverman, Stuart G., Nagy, Rebecca J., Lanman, Richard B., Knoerzer, Deborah, Welsch, Dean J., Yurgelun, Matthew B., Fuchs, Charles S., Garraway, Levi A., Getz, Gad, Hornick, Jason L., Johnson, Bruce E., Kulke, Matthew H., Mayer, Robert J., Miller, Jeffrey W., Shyn, Paul B., Tuveson, David A., Wagle, Nikhil, Yeh, Jen Jen, Hahn, William C., Corcoran, Ryan B., Carter, Scott L., Wolpin, Brian M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6192263/
https://ncbi.nlm.nih.gov/pubmed/29903880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-18-0275
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