Convergent therapeutic strategies to overcome the heterogeneity of acquired resistance in BRAF(V600E) colorectal cancer

Clonal heterogeneity associated with acquired resistance presents a critical therapeutic challenge. Whole-exome sequencing of paired tumor biopsies and targeted sequencing of cell-free DNA (cfDNA) from BRAF(V600E) colorectal cancer patients receiving BRAF inhibitor combinations identified 14 distinc...

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Bibliografiske detaljer
Udgivet i:Cancer Discov
Main Authors: Hazar-Rethinam, Mehlika, Kleyman, Marianna, Han, G. Celine, Liu, David, Ahronian, Leanne G., Shahzade, Heather A., Chen, Lifeng, Parikh, Aparna R., Allen, Jill N., Clark, Jeffrey W., Kwak, Eunice L., Faris, Jason E., Murphy, Janet E., Hong, Theodore S., Van Seventer, Emily E., Nadres, Brandon, Hong, Catriona B., Gurski, Joseph M., Jessop, Nicholas A., Dias-Santagata, Dora, Iafrate, A. John, Van Allen, Eliezer M., Corcoran, Ryan B.
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882515/
https://ncbi.nlm.nih.gov/pubmed/29431697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1227
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