Convergent therapeutic strategies to overcome the heterogeneity of acquired resistance in BRAF(V600E) colorectal cancer

Clonal heterogeneity associated with acquired resistance presents a critical therapeutic challenge. Whole-exome sequencing of paired tumor biopsies and targeted sequencing of cell-free DNA (cfDNA) from BRAF(V600E) colorectal cancer patients receiving BRAF inhibitor combinations identified 14 distinc...

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Vydáno v:Cancer Discov
Hlavní autoři: Hazar-Rethinam, Mehlika, Kleyman, Marianna, Han, G. Celine, Liu, David, Ahronian, Leanne G., Shahzade, Heather A., Chen, Lifeng, Parikh, Aparna R., Allen, Jill N., Clark, Jeffrey W., Kwak, Eunice L., Faris, Jason E., Murphy, Janet E., Hong, Theodore S., Van Seventer, Emily E., Nadres, Brandon, Hong, Catriona B., Gurski, Joseph M., Jessop, Nicholas A., Dias-Santagata, Dora, Iafrate, A. John, Van Allen, Eliezer M., Corcoran, Ryan B.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5882515/
https://ncbi.nlm.nih.gov/pubmed/29431697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-1227
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