Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

par Bell, Andrew S., Mills, James E., Williams, Gareth P., Brannigan, James A., Wilkinson, Anthony J., Parkinson, Tanya, Leatherbarrow, Robin J., Tate, Edward W., Holder, Anthony A., Smith, Deborah F.
Publié 2012

Continuing analysis of microRNA origins: Formation from transposable element insertions and noncoding RNA mutations

par Roberts, Justin T, Cooper, Elvera A, Favreau, Connor J, Howell, Jacob S, Lane, Lee G, Mills, James E, Newman, Derrick C, Perry, Tabitha J, Russell, Meaghan E, Wallace, Brittany M, Borchert, Glen M
Publié 2013

Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

par Zirimwabagabo, Jean-Olivier, Jailani, Ameera B. A., Avgoustou, Paris, Tozer, Matthew J., Gibson, Karl R., Glossop, Paul A., Mills, James E. J., Porter, Roderick A., Blaney, Paul, Wang, Ning, Skerry, Timothy M., Richards, Gareth O., Harrity, Joseph P. A.
Publié dans J Med Chem (2021)

Novel Oxindole Sulfonamides and Sulfamides: EPZ031686, the First Orally Bioavailable Small Molecule SMYD3 Inhibitor

par Mitchell, Lorna H., Boriack-Sjodin, P. Ann, Smith, Sherri, Thomenius, Michael, Rioux, Nathalie, Munchhof, Michael, Mills, James E., Klaus, Christine, Totman, Jennifer, Riera, Thomas V., Raimondi, Alejandra, Jacques, Suzanne L., West, Kip, Foley, Megan, Waters, Nigel J., Kuntz, Kevin W., Wigle, Tim J., Scott, Margaret Porter, Copeland, Robert A., Smith, Jesse J., Chesworth, Richard
Publié dans ACS Med Chem Lett (2015)

Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor

par Avgoustou, Paris, Jailani, Ameera B. A., Zirimwabagabo, Jean-Olivier, Tozer, Matthew J., Gibson, Karl R., Glossop, Paul A., Mills, James E. J., Porter, Roderick A., Blaney, Paul, Bungay, Peter J., Wang, Ning, Shaw, Alice P., Bigos, Kamilla J. A., Holmes, Joseph L., Warrington, Jessica I., Skerry, Timothy M., Harrity, Joseph P. A., Richards, Gareth O.
Publié dans ACS Pharmacol Transl Sci (2020)

Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation

par Thomenius, Michael J., Totman, Jennifer, Harvey, Darren, Mitchell, Lorna H., Riera, Thomas V., Cosmopoulos, Kat, Grassian, Alexandra R., Klaus, Christine, Foley, Megan, Admirand, Elizabeth A., Jahic, Haris, Majer, Christina, Wigle, Tim, Jacques, Suzanne L., Gureasko, Jodi, Brach, Dorothy, Lingaraj, Trupti, West, Kip, Smith, Sherri, Rioux, Nathalie, Waters, Nigel J., Tang, Cuyue, Raimondi, Alejandra, Munchhof, Michael, Mills, James E., Ribich, Scott, Porter Scott, Margaret, Kuntz, Kevin W., Janzen, William P., Moyer, Mikel, Smith, Jesse J., Chesworth, Richard, Copeland, Robert A., Boriack-Sjodin, P. Ann
Publié dans PLoS One (2018)