Discovery of a First-in-Class Potent Small Molecule Antagonist against the Adrenomedullin-2 Receptor

[Image: see text] The hormone adrenomedullin has both physiological and pathological roles in biology. As a potent vasodilator, adrenomedullin is critically important in the regulation of blood pressure, but it also has several roles in disease, of which its actions in cancer are becoming recognized...

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Detalhes bibliográficos
Publicado no:ACS Pharmacol Transl Sci
Main Authors: Avgoustou, Paris, Jailani, Ameera B. A., Zirimwabagabo, Jean-Olivier, Tozer, Matthew J., Gibson, Karl R., Glossop, Paul A., Mills, James E. J., Porter, Roderick A., Blaney, Paul, Bungay, Peter J., Wang, Ning, Shaw, Alice P., Bigos, Kamilla J. A., Holmes, Joseph L., Warrington, Jessica I., Skerry, Timothy M., Harrity, Joseph P. A., Richards, Gareth O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7432679/
https://ncbi.nlm.nih.gov/pubmed/32832872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsptsci.0c00032
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