Discovery of a First-In-Class Small Molecule Antagonist against the Adrenomedullin-2 Receptor: Structure–Activity Relationships and Optimization

[Image: see text] Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or cal...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Zirimwabagabo, Jean-Olivier, Jailani, Ameera B. A., Avgoustou, Paris, Tozer, Matthew J., Gibson, Karl R., Glossop, Paul A., Mills, James E. J., Porter, Roderick A., Blaney, Paul, Wang, Ning, Skerry, Timothy M., Richards, Gareth O., Harrity, Joseph P. A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8006142/
https://ncbi.nlm.nih.gov/pubmed/33666424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c02191
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