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Discovery of Octahydroindenes as PAR1 Antagonists
[Image: see text] Octahydroindene was identified as a novel scaffold for protease activated receptor 1 (PAR1) antagonists. Herein, the 2-position (C2) was explored for structure–activity relationship (SAR) studies. Compounds 14, 19, and 23b showed IC(50) values of 1.3, 8.6, and 2.7 nM in a PAR1 radi...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Chemical Society
2013
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| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4027540/ https://ncbi.nlm.nih.gov/pubmed/24900604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400235c |
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