Discovery of Tetrahydroisoquinoline-Based CXCR4 Antagonists

[Image: see text] A de novo hit-to-lead effort involving the redesign of benzimidazole-containing antagonists of the CXCR4 receptor resulted in the discovery of a novel series of 1,2,3,4-tetrahydroisoquinoline (TIQ) analogues. In general, this series of compounds show good potencies (3–650 nM) in as...

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Detalhes bibliográficos
Main Authors: Truax, Valarie M., Zhao, Huanyu, Katzman, Brooke M., Prosser, Anthony R., Alcaraz, Ana A., Saindane, Manohar T., Howard, Randy B., Culver, Deborah, Arrendale, Richard F., Gruddanti, Prahbakar R., Evers, Taylor J., Natchus, Michael G., Snyder, James P., Liotta, Dennis C., Wilson, Lawrence J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4057008/
https://ncbi.nlm.nih.gov/pubmed/24936240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400183q
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