Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor

[Image: see text] The rationale for the structural and mechanistic basis of a tetrahydroisoquinoline (THIQ) based series of CXCR4 antagonists is presented. Using the previously reported crystal structures which reveal two distinct binding sites of CXCR4 defined as the small molecule (IT1t or minor)...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:ACS Med Chem Lett
Main Authors: Katzman, Brooke M., Cox, Bryan D., Prosser, Anthony R., Alcaraz, Ana A., Murat, Brigitte, Héroux, Madeleine, Tebben, Andrew, Zhang, Yong, Schroeder, Gretchen M., Snyder, James P., Wilson, Lawrence J., Liotta, Dennis C.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2018
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331156/
https://ncbi.nlm.nih.gov/pubmed/30655949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00441
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki