Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor

[Image: see text] The rationale for the structural and mechanistic basis of a tetrahydroisoquinoline (THIQ) based series of CXCR4 antagonists is presented. Using the previously reported crystal structures which reveal two distinct binding sites of CXCR4 defined as the small molecule (IT1t or minor)...

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Publicado en:ACS Med Chem Lett
Autores principales: Katzman, Brooke M., Cox, Bryan D., Prosser, Anthony R., Alcaraz, Ana A., Murat, Brigitte, Héroux, Madeleine, Tebben, Andrew, Zhang, Yong, Schroeder, Gretchen M., Snyder, James P., Wilson, Lawrence J., Liotta, Dennis C.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2018
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6331156/
https://ncbi.nlm.nih.gov/pubmed/30655949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00441
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