Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists

[Image: see text] CXCR4 is the most common chemokine receptor expressed on the surface of many cancer cell types. In comparison to normal cells, cancer cells overexpress CXCR4, which correlates with cancer cell metastasis, angiogenesis, and tumor growth. CXCR4 antagonists can potentially diminish th...

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Bibliografski detalji
Izdano u:ACS Med Chem Lett
Glavni autori: Wilson, Robert J., Jecs, Edgars, Miller, Eric J., Nguyen, Huy H., Tahirovic, Yesim A., Truax, Valarie M., Kim, Michelle B., Kuo, Katie M., Wang, Tao, Sum, Chi Shing, Cvijic, Mary E., Paiva, Anthony A., Schroeder, Gretchen M., Wilson, Lawrence J., Liotta, Dennis C.
Format: Artigo
Jezik:Inglês
Izdano: American Chemical Society 2017
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767887/
https://ncbi.nlm.nih.gov/pubmed/29348805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00381
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