Synthesis and SAR of 1,2,3,4-Tetrahydroisoquinoline-Based CXCR4 Antagonists

[Image: see text] CXCR4 is the most common chemokine receptor expressed on the surface of many cancer cell types. In comparison to normal cells, cancer cells overexpress CXCR4, which correlates with cancer cell metastasis, angiogenesis, and tumor growth. CXCR4 antagonists can potentially diminish th...

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Bibliographic Details
Published in:ACS Med Chem Lett
Main Authors: Wilson, Robert J., Jecs, Edgars, Miller, Eric J., Nguyen, Huy H., Tahirovic, Yesim A., Truax, Valarie M., Kim, Michelle B., Kuo, Katie M., Wang, Tao, Sum, Chi Shing, Cvijic, Mary E., Paiva, Anthony A., Schroeder, Gretchen M., Wilson, Lawrence J., Liotta, Dennis C.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2017
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5767887/
https://ncbi.nlm.nih.gov/pubmed/29348805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00381
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