Learning from the past for TB drug discovery in the future

door Mikušová, Katarína, Ekins, Sean
Gepubliceerd in Drug Discov Today (2016)

Biosynthesis of Galactan in Mycobacterium tuberculosis as a Viable TB Drug Target?

door Konyariková, Zuzana, Savková, Karin, Kozmon, Stanislav, Mikušová, Katarína
Gepubliceerd in Antibiotics (Basel) (2020)

Purification and characterization of the acyltransferase involved in biosynthesis of the major mycobacterial cell envelope glycolipid - monoacylated phosphatidylinositol dimannosid...

door Svetlíková, Zuzana, Baráth, Peter, Jackson, Mary, Korduláková, Jana, Mikušová, Katarína
Gepubliceerd in 2014

Synthesis, docking study and biological evaluation of ᴅ-fructofuranosyl and ᴅ-tagatofuranosyl sulfones as potential inhibitors of the mycobacterial galactan synthesis targeting the...

door Baráth, Marek, Jakubčinová, Jana, Konyariková, Zuzana, Kozmon, Stanislav, Mikušová, Katarína, Bella, Maroš
Gepubliceerd in Beilstein J Org Chem (2020)

Investigation of ABC transporter from mycobacterial arabinogalactan biosynthetic cluster

door Dianišková, Petronela, Korduláková, Jana, Škovierová, Henrieta, Kaur, Devinder, Jackson, Mary, Brennan, Patrick J., Mikušová, Katarína
Gepubliceerd in Gen Physiol Biophys (2011)

Galactosyl Transferases in Mycobacterial Cell Wall Synthesis

door Beláňová, Martina, Dianišková, Petronela, Brennan, Patrick J., Completo, Gladys C., Rose, Natisha L., Lowary, Todd L., Mikušová, Katarína
Gepubliceerd in 2008

Identification of a Novel Galactosyl Transferase Involved in Biosynthesis of the Mycobacterial Cell Wall

door Mikušová, Katarína, Beláňová, Martina, Korduláková, Jana, Honda, Kristine, McNeil, Michael R., Mahapatra, Sebabrata, Crick, Dean C., Brennan, Patrick J.
Gepubliceerd in 2006

GtrA Protein Rv3789 Is Required for Arabinosylation of Arabinogalactan in Mycobacterium tuberculosis

door Kolly, Gaëlle S., Mukherjee, Raju, Kilacsková, Emöke, Abriata, Luciano A., Raccaud, Mahé, Blaško, Jaroslav, Sala, Claudia, Dal Peraro, Matteo, Mikušová, Katarína, Cole, Stewart T.
Gepubliceerd in J Bacteriol (2015)

N-Acetylglucosamine-1-Phosphate Transferase, WecA, as a Validated Drug Target in Mycobacterium tuberculosis

door Huszár, Stanislav, Singh, Vinayak, Polčicová, Alica, Baráth, Peter, Barrio, María Belén, Lagrange, Sophie, Leblanc, Véronique, Nacy, Carol A., Mizrahi, Valerie, Mikušová, Katarína
Gepubliceerd in Antimicrob Agents Chemother (2017)

An ABC transporter Wzm–Wzt catalyzes translocation of lipid-linked galactan across the plasma membrane in mycobacteria

door Savková, Karin, Huszár, Stanislav, Baráth, Peter, Pakanová, Zuzana, Kozmon, Stanislav, Vancová, Marie, Tesařová, Martina, Blaško, Jaroslav, Kaliňák, Michal, Singh, Vinayak, Korduláková, Jana, Mikušová, Katarína
Gepubliceerd in Proc Natl Acad Sci U S A (2021)

Decaprenylphosphoryl Arabinofuranose, the Donor of the d-Arabinofuranosyl Residues of Mycobacterial Arabinan, Is Formed via a Two-Step Epimerization of Decaprenylphosphoryl Ribose

door Mikušová, Katarína, Huang, Hairong, Yagi, Tetsuya, Holsters, Marcelle, Vereecke, Danny, D'Haeze, Wim, Scherman, Michael S., Brennan, Patrick J., McNeil, Michael R., Crick, Dean C.
Gepubliceerd in 2005

Drugging the Folate Pathway in Mycobacterium Tuberculosis: The Role of Multi-Targeting Agents

door Hajian, Behnoush, Scocchera, Eric, Shoen, Carolyn, Krucinska, Jolanta, Viswanathan, Kishore, G-Dayanandan, Narendran, Erlandsen, Heidi, Estrada, Alexavier, Mikušová, Katarína, Korduláková, Jana, Cynamon, Michael, Wright, Dennis
Gepubliceerd in Cell Chem Biol (2019)

Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

door Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G., Dias, David M. G., Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G., Blundell, Tom L., Abell, Chris
Gepubliceerd in J Med Chem (2020)

Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors

door Sabbah, Mohamad, Mendes, Vitor, Vistal, Robert G., Dias, David M. G., Záhorszká, Monika, Mikušová, Katarína, Korduláková, Jana, Coyne, Anthony G., Blundell, Tom L., Abell, Chris
Gepubliceerd in J Med Chem (2020)

Design, Syntheses, and Anti-TB Activity of 1,3-Benzothiazinone Azide and Click Chemistry Products Inspired by BTZ043

door Tiwari, Rohit, Miller, Patricia A., Chiarelli, Laurent R., Mori, Giorgia, Šarkan, Michal, Centárová, Ivana, Cho, Sanghyun, Mikušová, Katarína, Franzblau, Scott G., Oliver, Allen G., Miller, Marvin J.
Gepubliceerd in ACS Med Chem Lett (2016)

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds

door Liu, Rui, Markley, Lowell, Miller, Patricia A., Franzblau, Scott, Shetye, Gauri, Ma, Rui, Savková, Karin, Mikušová, Katarína, Lee, Bei Shi, Pethe, Kevin, Moraski, Garrett C., Miller, Marvin J.
Gepubliceerd in RSC Med Chem (2021)

Biosynthetic Origin of the Galactosamine Substituent of Arabinogalactan in Mycobacterium tuberculosis

door Škovierová, Henrieta, Larrouy-Maumus, Gérald, Pham, Ha, Belanová, Martina, Barilone, Nathalie, DasGupta, Arunava, Mikušová, Katarina, Gicquel, Brigitte, Gilleron, Martine, Brennan, Patrick. J., Puzo, Germain, Nigou, Jérôme, Jackson, Mary
Gepubliceerd in 2010

The 8-Pyrrole-Benzothiazinones Are Noncovalent Inhibitors of DprE1 from Mycobacterium tuberculosis

door Makarov, Vadim, Neres, João, Hartkoorn, Ruben C., Ryabova, Olga B., Kazakova, Elena, Šarkan, Michal, Huszár, Stanislav, Piton, Jérémie, Kolly, Gaëlle S., Vocat, Anthony, Conroy, Trent M., Mikušová, Katarína, Cole, Stewart T.
Gepubliceerd in Antimicrob Agents Chemother (2015)

Synthetic UDP-furanoses as potent inhibitors of mycobacterial galactan biogenesis

door Peltier, Pauline, Beláňová, Martina, Dianišková, Petronela, Zhou, Ruokun, Zheng, Ruixiang Blake, Pearcey, Jean A., Joe, Maju, Brennan, Patrick J., Nugier-Chauvin, Caroline, Ferrières, Vincent, Lowary, Todd L., Daniellou, Richard, Mikušová, Katarína
Gepubliceerd in 2010

Structural basis for selective recognition of acyl chains by the membrane-associated acyltransferase PatA

door Albesa-Jové, David, Svetlíková, Zuzana, Tersa, Montse, Sancho-Vaello, Enea, Carreras-González, Ana, Bonnet, Pascal, Arrasate, Pedro, Eguskiza, Ander, Angala, Shiva K., Cifuente, Javier O., Korduláková, Jana, Jackson, Mary, Mikušová, Katarína, Guerin, Marcelo E.
Gepubliceerd in Nat Commun (2016)