Inhibitors of energy metabolism interfere with antibiotic-induced death in mycobacteria

Autor Lee, Bei Shi, Kalia, Nitin P., Jin, Xin Er F., Hasenoehrl, Erik J., Berney, Michael, Pethe, Kevin
Vydáno v J Biol Chem (2019)

Structure guided generation of thieno[3,2-d]pyrimidin-4-amine Mycobacterium tuberculosis bd oxidase inhibitors

Autor Hopfner, Sarah M., Lee, Bei Shi, Kalia, Nitin P., Miller, Marvin J., Pethe, Kevin, Moraski, Garrett C.
Vydáno v RSC Med Chem (2021)

Hydride-induced Meisenheimer complex formation reflects activity of nitro aromatic anti-tuberculosis compounds

Autor Liu, Rui, Markley, Lowell, Miller, Patricia A., Franzblau, Scott, Shetye, Gauri, Ma, Rui, Savková, Karin, Mikušová, Katarína, Lee, Bei Shi, Pethe, Kevin, Moraski, Garrett C., Miller, Marvin J.
Vydáno v RSC Med Chem (2021)

Bedaquiline reprograms central metabolism to reveal glycolytic vulnerability in Mycobacterium tuberculosis

Autor Mackenzie, Jared S., Lamprecht, Dirk A., Asmal, Rukaya, Adamson, John H., Borah, Khushboo, Beste, Dany J. V., Lee, Bei Shi, Pethe, Kevin, Rousseau, Simon, Krieger, Inna, Sacchettini, James C., Glasgow, Joel N., Steyn, Adrie J. C.
Vydáno v Nat Commun (2020)

Dual inhibition of the terminal oxidases eradicates antibiotic‐tolerant Mycobacterium tuberculosis

Autor Lee, Bei Shi, Hards, Kiel, Engelhart, Curtis A, Hasenoehrl, Erik J, Kalia, Nitin P, Mackenzie, Jared S, Sviriaeva, Ekaterina, Chong, Shi Min Sherilyn, Manimekalai, Malathy Sony S, Koh, Vanessa H, Chan, John, Xu, Jiayong, Alonso, Sylvie, Miller, Marvin J, Steyn, Adrie J C, Grüber, Gerhard, Schnappinger, Dirk, Berney, Michael, Cook, Gregory M, Moraski, Garrett C, Pethe, Kevin
Vydáno v EMBO Mol Med (2020)