Drugging the Folate Pathway in Mycobacterium Tuberculosis: The Role of Multi-Targeting Agents

The folate biosynthetic pathway offers many druggable targets that have yet to be exploited in TB therapy. Herein, we have identified a series of small molecules that interrupt Mycobacterium tuberculosis folate metabolism by dual targeting of dihydrofolate reductase (DHFR), a key enzyme in the folat...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Hajian, Behnoush, Scocchera, Eric, Shoen, Carolyn, Krucinska, Jolanta, Viswanathan, Kishore, G-Dayanandan, Narendran, Erlandsen, Heidi, Estrada, Alexavier, Mikušová, Katarína, Korduláková, Jana, Cynamon, Michael, Wright, Dennis
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6588435/
https://ncbi.nlm.nih.gov/pubmed/30930162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2019.02.013
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