MRSA isolates from the United States hospitals carry dfrG and dfrK resistance genes and succumb to propargyl-linked antifolates

Antibiotic resistance is a rapidly evolving health concern that requires a sustained effort to understand mechanisms of resistance and develop new agents that overcome those mechanisms. The dihydrofolate reductase (DHFR) inhibitor, trimethoprim (TMP), remains one of the most important orally adminis...

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Veröffentlicht in:Cell Chem Biol
Hauptverfasser: Reeve, Stephanie M., Scocchera, Eric W., G-Dayanadan, Narendran, Keshipeddy, Santosh, Krucinska, Jolanta, Hajian, Behnoush, Ferreira, Jacob, Nailor, Michael, Aeschlimann, Jeffrey, Wright, Dennis L., Anderson, Amy C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5228619/
https://ncbi.nlm.nih.gov/pubmed/27939900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2016.11.007
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