Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein–ligand interactions including a structural basis for observed ant...

Por Anderson, Amy C.
Publicado em 2005

Winning the Arms Race by Improving Drug Discovery against Mutating Targets

Por Anderson, Amy C.
Publicado em 2011

Structure-Based Functional Design of Drugs: From Target to Lead Compound

Por Anderson, Amy C.
Publicado em 2012

Structure-Activity Relationships of Bacillus cereus and Bacillus anthracis Dihydrofolate Reductase: toward the Identification of New Potent Drug Leads

Por Joska, Tammy M., Anderson, Amy C.
Publicado em 2006

In pursuit of virtual lead optimization: Pruning ensembles of receptor structures for increased efficiency and accuracy during docking

Por Bolstad, Erin S. D., Anderson, Amy C.
Publicado em 2009

Scoring Ensembles of Docked Protein:Ligand Interactions for Virtual Lead Optimization

Por Paulsen, Janet L., Anderson, Amy C.
Publicado em 2009

Antifolate Agents: A Patent Review (2006–2010)

Por Wright, Dennis L., Anderson, Amy C.
Publicado em 2011

In pursuit of virtual lead optimization: The role of the receptor structure and ensembles in accurate docking

Por Bolstad, Erin S. D., Anderson, Amy C.
Publicado em 2008

The Challenge of Resistance in Antimicrobial Drug Development

Por Anderson, Amy C, Wright, Dennis L
Publicado no Future Microbiol (2015)

2,4-Diamino-5-(2′-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition

Por Algul, Oztekin, Paulsen, Janet L., Anderson, Amy C.
Publicado em 2010

Antibacterial Antifolates: From Development through Resistance to the Next Generation

Por Estrada, Alexavier, Wright, Dennis L., Anderson, Amy C.
Publicado no Cold Spring Harb Perspect Med (2016)

Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency...

Por Paulsen, Janet L., Bendel, Stephen D., Anderson, Amy C.
Publicado em 2011

Targeted Mutations of Bacillus anthracis Dihydrofolate Reductase Condense Complex Structure-Activity Relationships

Por Beierlein, Jennifer M., Karri, Nanda G., Anderson, Amy C.
Publicado em 2010

Understanding the structural mechanisms of antibiotic resistance sets the platform for new discovery

Por Reeve, Stephanie M, Lombardo, Michael N, Anderson, Amy C
Publicado no Future Microbiol (2015)

The challenge of developing robust drugs to overcome resistance

Por Anderson, Amy C., Schiffer, Celia, Pollastri, Michael, Peet, Norton P.
Publicado em 2011

Computational structure-based redesign of enzyme activity

Por Chen, Cheng-Yu, Georgiev, Ivelin, Anderson, Amy C., Donald, Bruce R.
Publicado em 2009

Predicting resistance mutations using protein design algorithms

Por Frey, Kathleen M., Georgiev, Ivelin, Donald, Bruce R., Anderson, Amy C.
Publicado em 2010

Prospective Screening of Novel Antibacterial Inhibitors of Dihydrofolate Reductase for Mutational Resistance

Por Frey, Kathleen M., Viswanathan, Kishore, Wright, Dennis L., Anderson, Amy C.
Publicado em 2012

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species

Por Paulsen, Janet L., Viswanathan, Kishore, Wright, Dennis L., Anderson, Amy C.
Publicado em 2013

Non-racemic Antifolates Stereo-selectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus

Por Keshipeddy, Santosh, Reeve, Stephanie M., Anderson, Amy C., Wright, Dennis L.
Publicado no J Am Chem Soc (2015)