Finding New Collaboration Models for Enabling Neglected Tropical Disease Drug Discovery

Por Pollastri, Michael P.
Publicado em 2014

Fexinidazole: A New Drug for African Sleeping Sickness on the Horizon

Por Pollastri, Michael P.
Publicado no Trends Parasitol (2017)

The importance of collaboration between industry, academics, and non-profits in tropical disease drug discovery.

Por Ferrins, Lori, Pollastri, Michael P.
Publicado no ACS Infect Dis (2017)

Target repurposing for neglected diseases

Por Pollastri, Michael P, Campbell, Robert K
Publicado em 2011

REPURPOSING STRATEGIES FOR TROPICAL DISEASE DRUG DISCOVERY

Por Klug, Dana M., Gelb, Michael H., Pollastri, Michael P.
Publicado no Bioorg Med Chem Lett (2016)

The challenge of developing robust drugs to overcome resistance

Por Anderson, Amy C., Schiffer, Celia, Pollastri, Michael, Peet, Norton P.
Publicado em 2011

Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

Por Thomas, Sarah M., Purmal, Andrei, Pollastri, Michael, Mensa-Wilmot, Kojo
Publicado no Sci Rep (2016)

Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis

Por Thomas, Sarah M., Purmal, Andrei, Pollastri, Michael, Mensa-Wilmot, Kojo
Publicado no Sci Rep (2017)

Evaluation of pyrrolidine and pyrazolone derivatives as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

Por Amata, Emanuele, Bland, Nicholas D., Campbell, Robert K., Pollastri, Michael P.
Publicado no Tetrahedron Lett (2015)

Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies

Por Guyett, Paul J., Behera, Ranjan, Ogata, Yuko, Pollastri, Michael, Mensa-Wilmot, Kojo
Publicado no Antimicrob Agents Chemother (2017)

Identification and characterization of Kava-derived compounds mediating TNF-α suppression

Por Pollastri, Michael P., Whitty, Adrian, Merrill, Jamie Cassidy, Ashton, Trent D., Amar, Salomon
Publicado em 2009

Kinases as Druggable Targets in Trypanosomatid Protozoan Parasites

Por Merritt, Christopher, Silva, Lisseth E., Tanner, Angela L., Stuart, Kenneth, Pollastri, Michael P.
Publicado no Chem Rev (2014)

Glycogen Synthase Kinase 3β Promotes the Endocytosis of Transferrin in the African Trypanosome

Por Guyett, Paul J., Xia, Shuangluo, Swinney, David C., Pollastri, Michael, Mensa-Wilmot, Kojo
Publicado no ACS Infect Dis (2016)

Optimization of Physicochemical Properties for 4-Anilinoquinoline Inhibitors of Plasmodium falciparum Proliferation

Por Mehta, Naimee, Ferrins, Lori, Leed, Susan E., Sciotti, Richard J., Pollastri, Michael P.
Publicado no ACS Infect Dis (2018)

Repurposing human PDE4 inhibitors for neglected tropical diseases. Evaluation of analogs of the human PDE4 inhibitor GSK-256066 as inhibitors of PDEB1 of Trypanosoma brucei

Por Ochiana, Stefan O., Bland, Nicholas D., Settimo, Luca, Campbell, Robert K., Pollastri, Michael P.
Publicado no Chem Biol Drug Des (2014)

Synthesis and assessment of catechol diether compounds as inhibitors of trypanosomal phosphodiesterase B1 (TbrPDEB1)

Por Woodring, Jennifer L., Bland, Nicholas D., Ochiana, Stefan O., Campbell, Robert K., Pollastri, Michael P.
Publicado em 2013

Repurposing human PDE4 inhibitors for neglected tropical diseases: Design, synthesis and evaluation of cilomilast analogues as Trypanosoma brucei PDEB1 inhibitors

Por Amata, Emanuele, Bland, Nicholas D., Hoyt, Charles T., Settimo, Luca, Campbell, Robert K., Pollastri, Michael P.
Publicado em 2014

The human Aurora kinase inhibitor danusertib is a lead compound for anti-trypanosomal drug discovery via target repurposing

Por Ochiana, Stefan O., Pandarinath, Vidya, Wang, Zhouxi, Kapoor, Rishika, Ondrechen, Mary Jo, Ruben, Larry, Pollastri, Michael P.
Publicado em 2012

A Chemical Screen Identifies Small Molecules that Regulate Hepcidin Expression

Por Gaun, Vera, Patchen, Bonnie, Volovetz, Josephine, Zhen, Aileen W., Andreev, Aleksandr, Pollastri, Michael P., Fraenkel, Paula G.
Publicado em 2014

Calcium-Dependent Protein Kinase 5 Is Required for Release of Egress-Specific Organelles in Plasmodium falciparum

Por Absalon, Sabrina, Blomqvist, Karin, Rudlaff, Rachel M., DeLano, Travis J., Pollastri, Michael P., Dvorin, Jeffrey D.
Publicado no mBio (2018)