Decomposing the Energetic Impact of Drug-Resistant Mutations: The Example of HIV-1 Protease - DRV Binding

Por Cai, Yufeng, Schiffer, Celia
Publicado no Methods Mol Biol (2012)

Resilience to Resistance of HIV-1 Protease Inhibitors: Profile of Darunavir

Por Lefebvre, Eric, Schiffer, Celia A.
Publicado em 2008

Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV

Por Cai, Yufeng, Schiffer, Celia A
Publicado em 2010

REdiii: a pipeline for automated structure solution

Por Bohn, Markus-Frederik, Schiffer, Celia A.
Publicado no Acta Crystallogr D Biol Crystallogr (2015)

APOBEC3s: DNA‐editing human cytidine deaminases

Por Silvas, Tania V., Schiffer, Celia A.
Publicado no Protein Sci (2019)

Structure-Based Prediction of Potential Binding and Nonbinding Peptides to HIV-1 Protease

Por Kurt, Nese, Haliloglu, Turkan, Schiffer, Celia A.
Publicado em 2003

New Approaches to HIV Protease Inhibitor Drug Design II: Testing the substrate envelope hypothesis to avoid drug resistance and discover robust inhibitors

Por Nalam, Madhavi N. L., Schiffer, Celia A.
Publicado em 2008

Rationale for More Diverse Inhibitors in Competition with Substrates in HIV-1 Protease

Por Ozer, Nevra, Schiffer, Celia A., Haliloglu, Turkan
Publicado em 2010

Dynamics of Preferential Substrate Recognition in HIV-1 Protease: Redefining the Substrate Envelope

Por Özen, Ayşegül, Haliloğlu, Türkan, Schiffer, Celia A.
Publicado em 2011

HIV-1 Protease and Substrate Coevolution Validates the Substrate Envelope As the Substrate Recognition Pattern

Por Özen, Ayşegül, Haliloğlu, Türkan, Schiffer, Celia A.
Publicado em 2012

Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design

Por Özen, Ayşegül, Sherman, Woody, Schiffer, Celia A.
Publicado em 2013

Structural Analysis of Asunaprevir Resistance in HCV NS3/4A Protease

Por Soumana, Djadé I., Ali, Akbar, Schiffer, Celia A.
Publicado no ACS Chem Biol (2014)

Improving Viral Protease Inhibitors to Counter Drug Resistance

Por Yilmaz, Nese Kurt, Swanstrom, Ronald, Schiffer, Celia A.
Publicado no Trends Microbiol (2016)

Target-Specific Prediction of Ligand Affinity with Structure-Based Interaction Fingerprints

Por Leidner, Florian, Kurt Yilmaz, Nese, Schiffer, Celia A.
Publicado no J Chem Inf Model (2019)

NMR and MD studies combined to elucidate inhibitor and water interactions of HIV-1 protease and their modulations with resistance mutations

Por Ishima, Rieko, Kurt-Yilmaz, Nese, Schiffer, Celia A.
Publicado no J Biomol NMR (2019)

Human Immunodeficiency Virus Type 1 Protease-Correlated Cleavage Site Mutations Enhance Inhibitor Resistance

Por Kolli, Madhavi, Stawiski, Eric, Chappey, Colombe, Schiffer, Celia A.
Publicado em 2009

Drug-resistant HIV-1 protease regains functional dynamics through cleavage site coevolution

Por Özer, Nevra, Özen, Ayşegül, Schiffer, Celia A, Haliloğlu, Türkan
Publicado no Evol Appl (2015)

Quantitative comparison of errors in (15)N transverse relaxation rates measured using various CPMG phasing schemes

Por Myint, Wazo, Cai, Yufeng, Schiffer, Celia A., Ishima, Rieko
Publicado no J Biomol NMR (2012)

Viral Protease Inhibitors

Por Anderson, Jeffrey, Schiffer, Celia, Lee, Sook-Kyung, Swanstrom, Ronald
Publicado no Antiviral Strategies (2009)

NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP)

Por Nichols, Jeffry C., Schiffer, Celia A., Royer, William E.
Publicado no J Biol Chem (2021)