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Decomposing the energetic impact of drug resistant mutations in HIV-1 protease on binding DRV
Darunavir (DRV) is a high affinity (4.5×10(-12) M, ΔG = -15.2 kcal/mol) HIV-1 protease inhibitor. Two drug-resistant protease variants FLAP+ (L10I, G48V, I54V, V82A) and ACT (V82T, I84V) decrease the binding affinity with DRV by 1.0 kcal/mol and 1.6 kcal/mol respectively. In this study the absolute...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2882104/ https://ncbi.nlm.nih.gov/pubmed/20543885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct9004678 |
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