Human Immunodeficiency Virus Type 1 Protease-Correlated Cleavage Site Mutations Enhance Inhibitor Resistance

Drug resistance is an important cause of antiretroviral therapy failure in human immunodeficiency virus (HIV)-infected patients. Mutations in the protease render the virus resistant to protease inhibitors (PIs). Gag cleavage sites also mutate, sometimes correlating with resistance mutations in the p...

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Bibliographische Detailangaben
Hauptverfasser: Kolli, Madhavi, Stawiski, Eric, Chappey, Colombe, Schiffer, Celia A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Genetic Diversity and Evolution
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772784/
https://ncbi.nlm.nih.gov/pubmed/19706699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00628-09
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