Context Surrounding Processing Sites Is Crucial in Determining Cleavage Rate of a Subset of Processing Sites in HIV-1 Gag and Gag-Pro-Pol Polyprotein Precursors by Viral Protease

Processing of the human immunodeficiency virus type 1 (HIV-1) Gag and Gag-Pro-Pol polyproteins by the HIV-1 protease (PR) is essential for the production of infectious particles. However, the determinants governing the rates of processing of these substrates are not clearly understood. We studied th...

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Detalhes bibliográficos
Main Authors: Lee, Sook-Kyung, Potempa, Marc, Kolli, Madhavi, Özen, Ayşegül, Schiffer, Celia A., Swanstrom, Ronald
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3339993/
https://ncbi.nlm.nih.gov/pubmed/22334652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.339374
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