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Improving the Resistance Profile of Hepatitis C NS3/4A Inhibitors: Dynamic Substrate Envelope Guided Design

Drug resistance is a principal concern in the treatment of quickly evolving diseases. The viral protease NS3/4A is a primary drug target for the hepatitis C virus (HCV) and is known to evolve resistance mutations in response to drug therapy. At the molecular level, drug resistance reflects a subtle...

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Bibliografiske detaljer
Main Authors: Özen, Ayşegül, Sherman, Woody, Schiffer, Celia A.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3935243/
https://ncbi.nlm.nih.gov/pubmed/24587770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ct400603p
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