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A Chemical Screen Identifies Small Molecules that Regulate Hepcidin Expression
Hepcidin, a peptide hormone produced in the liver, decreases intestinal iron absorption and macrophage iron release via effects on ferroportin. Bone morphogenic protein and Stat3 signaling regulate Hepcidin's transcription. Hepcidin is a potential drug target for patients with iron overload syn...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4198503/ https://ncbi.nlm.nih.gov/pubmed/24998898 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2014.06.002 |
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