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A Chemical Screen Identifies Small Molecules that Regulate Hepcidin Expression

Hepcidin, a peptide hormone produced in the liver, decreases intestinal iron absorption and macrophage iron release via effects on ferroportin. Bone morphogenic protein and Stat3 signaling regulate Hepcidin's transcription. Hepcidin is a potential drug target for patients with iron overload syn...

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Bibliografiska uppgifter
Huvudupphovsmän: Gaun, Vera, Patchen, Bonnie, Volovetz, Josephine, Zhen, Aileen W., Andreev, Aleksandr, Pollastri, Michael P., Fraenkel, Paula G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198503/
https://ncbi.nlm.nih.gov/pubmed/24998898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcmd.2014.06.002
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