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Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies
Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. Lapatinib, a human epidermal growth factor receptor (EGFR) inhibitor, can cure 25% of trypanosome-infected mice, although the parasite lacks EGFR-like tyrosine kinases. Four trypanosome...
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| Publicado no: | Antimicrob Agents Chemother |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5278746/ https://ncbi.nlm.nih.gov/pubmed/27872081 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01865-16 |
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