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AEE788 Inhibits Basal Body Assembly and Blocks DNA Replication in the African Trypanosome
Trypanosoma brucei causes human African trypanosomiasis (HAT). The pyrrolopyrimidine AEE788 (a hit for anti-HAT drug discovery) associates with three trypanosome protein kinases. Herein we delineate the effects of AEE788 on T. brucei using chemical biology strategies. AEE788 treatment inhibits DNA r...
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| Pubblicato in: | Mol Pharmacol |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5399642/ https://ncbi.nlm.nih.gov/pubmed/28246189 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.116.106906 |
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