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Novel Effects of Lapatinib Revealed in the African Trypanosome by Using Hypothesis-Generating Proteomics and Chemical Biology Strategies

Human African trypanosomiasis is a neglected tropical disease caused by the protozoan parasite Trypanosoma brucei. Lapatinib, a human epidermal growth factor receptor (EGFR) inhibitor, can cure 25% of trypanosome-infected mice, although the parasite lacks EGFR-like tyrosine kinases. Four trypanosome...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Guyett, Paul J., Behera, Ranjan, Ogata, Yuko, Pollastri, Michael, Mensa-Wilmot, Kojo
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5278746/
https://ncbi.nlm.nih.gov/pubmed/27872081
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01865-16
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