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Two crystal structures of dihydrofolate reductase-thymidylate synthase from Cryptosporidium hominis reveal protein–ligand interactions including a structural basis for observed antifolate resistance
Cryptosporidium hominis is a protozoan parasite that causes acute gastrointestinal illness. There are no effective therapies for cryptosporidiosis, highlighting the need for new drug-lead discovery. An analysis of the protein–ligand interactions in two crystal structures of dihydrofolate reductase-t...
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
International Union of Crystallography
2005
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| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1952288/ https://ncbi.nlm.nih.gov/pubmed/16511011 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309105002435 |
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