Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis Thymidylate Synthase-Dihydrofolate Reductase

Cryptosporidium is the causative agent of a gastrointestinal disease, cryptosporidiosis, which is often fatal in immunocompromised individuals and children. Thymidylate synthase (TS) and dihydrofolate reductase (DHFR) are essential enzymes in the folate biosynthesis pathway and are well established...

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Bibliografiset tiedot
Julkaisussa:Bioorg Med Chem Lett
Päätekijät: Kumar, Vidya P., Cisneros, Jose A., Frey, Kathleen M., Castellanos-Gonzalez, Alejandro, Wang, Yiqiang, Gangjee, Aleem, White, A. Clinton, Jorgensen, William L., Anderson, Karen S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4427026/
https://ncbi.nlm.nih.gov/pubmed/25127103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.049
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