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Substituted Pyrrolo[2,3-d]pyrimidines as Cryptosporidium hominis Thymidylate Synthase Inhibitors

Cryptosporidiosis, a gastrointestinal disease caused by a protozoan Cryptosporidium hominis is often fatal in immunocompromised individuals. There is little clinical data to show that the existing treatment by nitazoxanide and paromomycin is effective in immunocompromised individuals(1, 2). Thymidyl...

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Detalhes bibliográficos
Main Authors: Kumar, Vidya P., Frey, Kathleen M., Wang, Yiqiang, Jain, Hitesh K., Gangjee, Aleem, Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3853131/
https://ncbi.nlm.nih.gov/pubmed/23927969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.07.037
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