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Structural studies provide clues for analog design of specific inhibitors of Cryptosporidium hominis Thymidylate Synthase-Dihydrofolate Reductase
Cryptosporidium is the causative agent of a gastrointestinal disease, cryptosporidiosis, which is often fatal in immunocompromised individuals and children. Thymidylate synthase (TS) and dihydrofolate reductase (DHFR) are essential enzymes in the folate biosynthesis pathway and are well established...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Bioorg Med Chem Lett |
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| Κύριοι συγγραφείς: | , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
2014
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4427026/ https://ncbi.nlm.nih.gov/pubmed/25127103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2014.07.049 |
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