A nanotherapy strategy significantly enhances anticryptosporidial activity of an inhibitor of bifunctional thymidylate synthase-dihydrofolate reductase from Cryptosporidium

Cryptosporidiosis, a gastrointestinal disease caused by protozoans of the genus Cryptosporidium, is a common cause of diarrheal diseases and often fatal in immunocompromised individuals. Cryptosporidium hominis (C. hominis)-specific bifunctional thymidylate synthase-dihydrofolate reductase (TS-DHFR)...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Mukerjee, Anindita, Iyidogan, Pinar, Castellanos-Gonzalez, Alejandro, Cisneros, José A., Czyzyk, Daniel, Ranjan, Amalendu Prakash, Jorgensen, William L., White, A. Clinton, Vishwanatha, Jamboor K., Anderson, Karen S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416209/
https://ncbi.nlm.nih.gov/pubmed/25900220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.03.091
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