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Winning the Arms Race by Improving Drug Discovery against Mutating Targets
[Image: see text] Enzymes are often excellent drug targets. Yet drug pressure on an enzyme target often fosters the rise of cells with resistance-conferring mutations, some of which may compromise fitness and others that compensate to restore fitness. This review presents, first, a structural analys...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3649075/ https://ncbi.nlm.nih.gov/pubmed/22050347 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200394t |
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