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Winning the Arms Race by Improving Drug Discovery against Mutating Targets

[Image: see text] Enzymes are often excellent drug targets. Yet drug pressure on an enzyme target often fosters the rise of cells with resistance-conferring mutations, some of which may compromise fitness and others that compensate to restore fitness. This review presents, first, a structural analys...

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Bibliografski detalji
Glavni autor: Anderson, Amy C.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649075/
https://ncbi.nlm.nih.gov/pubmed/22050347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb200394t
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