Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates

Pharmacokinetic/pharmacodynamic properties are strongly correlated with the in vivo efficacy of antibiotics. Propargyl-linked antifolates, a novel class of antibiotics, demonstrate potent antibacterial activity against both Gram-positive and Gram-negative pathogenic bacteria, including multidrug-res...

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Publicat a:Drug Metab Dispos
Autors principals: Lombardo, M.N., G-Dayanandan, N., Keshipeddy, S., Zhou, W., Si, D., Reeve, S.M., Alverson, J., Barney, P., Walker, L., Hoody, J., Priestley, N.D., Obach, R.S., Wright, D.L.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184189/
https://ncbi.nlm.nih.gov/pubmed/31201212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.119.086504
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