Crystal Structures of Klebsiella pneumoniae Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal Features for Potency and Selectivity

Lignende værker

• Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates
  af: Cammarata, Michael, et al.
  Udgivet: (2017)
• Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata
  af: G-Dayanandan, Narendran, et al.
  Udgivet: (2014)
• Pharmaceutical Analysis of a Novel Propargyl-linked Antifolate Antibiotic in the Mouse
  af: Hoody, John, et al.
  Udgivet: (2017)
• Crystal structures of Candida albicans dihydrofolate reductase bound to propargyl-linked antifolates reveal the flexibility of active site loop residues critical for ligand potency and selectivity
  af: Paulsen, Janet L., et al.
  Udgivet: (2011)
• Elucidating features that drive the design of selective antifolates using crystal structures of human dihydrofolate reductase
  af: Lamb, Kristen M., et al.
  Udgivet: (2013)